A convenient method for 14C-labeling of N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-1H-pyrrole-2-carboxamide-[carboxy-14C] as CCK-A antagonist

被引：0

作者：

Saemian, Nader ^{[1
]}

Shirvani, Gholamhossein ^{[1
]}

机构：

[1] Nucl Sci & Technol Res Inst, Nucl Sci Res Sch, Tehran, Iran

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2012年 / 292卷 / 01期

关键词：

3-Substituted 1,4-benzodiazepine; Cholecystokinin antagonist; Carbon-14; EFFICIENT SYNTHESIS; POTENT; C-14;

D O I：

10.1007/s10967-011-1378-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-1H-pyrrole-2-carboxamide-[carboxy-C-14] was prepared as part of a five-step sequence from pyrrol-2-carbonitrile-[cyano-C-14] as a key synthetic intermediate which has been synthesized from 2-bromopyrrole and zinc [C-14]-cyanide in the presence of tetrakis (triphenylphosphine)palladium.

引用

页码：119 / 122

页数：4

共 16 条

[11] Synthesis of carbon-14 analogue of N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide-[carboxyl-14C] as CCK-A antagonist
Saemian, N
Shirvani, G
Matloubi, H
[J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2006, 49 (01) : 71 - 76
[12] Synthesis of a series of carbon-14 labelled 4-aminoquinazolines and quinazolin-4 (3H)-ones
Saemian, Nader
Arjomandi, Omid Khalili
Shirvani, Gholamhossein
[J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2009, 52 (11-12) : 453 - 456
[13] Synthesis of a carbon-14 analogue of aryl N-alkoxycarbamates and its application for synthesis of unsymmetrical N,N′-urea derivatives
Saemian, Nader
Shirvani, Gholamhossein
Javaheri, Mohsen
[J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 2009, 281 (03) : 421 - 423
[14] Fast and efficient synthesis of 14C labelled benzonitriles and their corresponding acids
Schou, Soren Christian
[J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2009, 52 (5-6) : 173 - 176
[15] AN IMPROVED SYNTHESIS AND RESOLUTION OF 3-AMINO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONES
SHERRILL, RG
SUGG, EE
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (03) : 730 - 734
[16] AN IMPROVED PROCEDURE FOR AROMATIC CYANATION
TSCHAEN, DM
DESMOND, R
KING, AO
FORTIN, MC
PIPIK, B
KING, S
VERHOEVEN, TR
[J]. SYNTHETIC COMMUNICATIONS, 1994, 24 (06) : 887 - 890

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