A convenient method for 14C-labeling of N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-1H-pyrrole-2-carboxamide-[carboxy-14C] as CCK-A antagonist

被引：0

作者：

Saemian, Nader ^{[1
]}

Shirvani, Gholamhossein ^{[1
]}

机构：

[1] Nucl Sci & Technol Res Inst, Nucl Sci Res Sch, Tehran, Iran

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2012年 / 292卷 / 01期

关键词：

3-Substituted 1,4-benzodiazepine; Cholecystokinin antagonist; Carbon-14; EFFICIENT SYNTHESIS; POTENT; C-14;

D O I：

10.1007/s10967-011-1378-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-1H-pyrrole-2-carboxamide-[carboxy-C-14] was prepared as part of a five-step sequence from pyrrol-2-carbonitrile-[cyano-C-14] as a key synthetic intermediate which has been synthesized from 2-bromopyrrole and zinc [C-14]-cyanide in the presence of tetrakis (triphenylphosphine)palladium.

引用

页码：119 / 122

页数：4

共 16 条

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