Mechanisms of FGFR-mediated carcinogenesis

被引：155
作者：
Ahmad, Imran [1 ,2 ]
Iwata, Tomoko [2 ]
Leung, Hing Y. [1 ,2 ]
机构：
[1] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland
[2] Univ Glasgow, Inst Canc Sci, Glasgow G31 2ER, Lanark, Scotland
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2012年 / 1823卷 / 04期
关键词：
FGF; FGFR; Receptor tyrosine kinase; Signalling; Cancer; Cancer therapy; FIBROBLAST-GROWTH-FACTOR; SQUAMOUS-CELL CARCINOMA; POTENTIAL THERAPEUTIC TARGET; TYROSINE KINASE INHIBITOR; GENOME-WIDE ASSOCIATION; FACTOR RECEPTOR-3 FGFR3; ACTIVATING MUTATIONS; BLADDER-CARCINOMA; MULTIPLE-MYELOMA; HEPATOCELLULAR-CARCINOMA;
D O I：
10.1016/j.bbamcr.2012.01.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review, the evidence for a role of fibroblast growth factor receptor (FGFR) mediated signalling in carcinogenesis are considered and relevant underlying mechanisms highlighted. FGF signalling mediated by FGFR follows a classic receptor tyrosine kinase signalling pathway and its deregulation at various points of its cascade could result in malignancy. Here we review the accumulating reports that revealed the association of FGF/FGFRs to various types of cancer at a genetic level, along with in vitro and in vivo evidences available so far, which indicates the functional involvement of FGF signalling in tumour formation and progression. An increasing number of drugs against the FGF pathways is currently in clinical testing. We will discuss the strategies for future FGF research in cancer and translational approaches. (c) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：850 / 860
页数：11
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