Mechanisms of FGFR-mediated carcinogenesis

被引：156

作者：

Ahmad, Imran ^{[1
,2
]}

Iwata, Tomoko ^{[2
]}

Leung, Hing Y. ^{[1
,2
]}

机构：

[1] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

[2] Univ Glasgow, Inst Canc Sci, Glasgow G31 2ER, Lanark, Scotland

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2012年 / 1823卷 / 04期

关键词：

FGF; FGFR; Receptor tyrosine kinase; Signalling; Cancer; Cancer therapy; FIBROBLAST-GROWTH-FACTOR; SQUAMOUS-CELL CARCINOMA; POTENTIAL THERAPEUTIC TARGET; TYROSINE KINASE INHIBITOR; GENOME-WIDE ASSOCIATION; FACTOR RECEPTOR-3 FGFR3; ACTIVATING MUTATIONS; BLADDER-CARCINOMA; MULTIPLE-MYELOMA; HEPATOCELLULAR-CARCINOMA;

D O I：

10.1016/j.bbamcr.2012.01.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this review, the evidence for a role of fibroblast growth factor receptor (FGFR) mediated signalling in carcinogenesis are considered and relevant underlying mechanisms highlighted. FGF signalling mediated by FGFR follows a classic receptor tyrosine kinase signalling pathway and its deregulation at various points of its cascade could result in malignancy. Here we review the accumulating reports that revealed the association of FGF/FGFRs to various types of cancer at a genetic level, along with in vitro and in vivo evidences available so far, which indicates the functional involvement of FGF signalling in tumour formation and progression. An increasing number of drugs against the FGF pathways is currently in clinical testing. We will discuss the strategies for future FGF research in cancer and translational approaches. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：850 / 860

页数：11

共 177 条

[1] Somatic FGF9 mutations in colorectal and endometrial carcinomas associated with membranous β-catenin [J].

Abdel-Rahman, Wael M. ;

Kalinina, Juliya ;

Shoman, Soheir ;

Eissa, Saad ;

Ollikainen, Miina ;

Elomaa, Outi ;

Eliseenkova, Anna V. ;

Butzow, Ralf ;

Mohammadi, Moosa ;

Peltomaki, Paivi .

HUMAN MUTATION, 2008, 29 (03) :390-397

[2] Breakdown of endocytosis in the oncogenic activation of receptor tyrosine kinases [J].

Abella, Jasmine V. ;

Park, Morag .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2009, 296 (05) :E973-E984

[3] Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial-to-mesenchymal transition [J].

Acevedo, Victor D. ;

Gangula, Rama D. ;

Freeman, Kevin W. ;

Li, Rile ;

Zhang, Youngyou ;

Wang, Fen ;

Ayala, Gustavo E. ;

Peterson, Leif E. ;

Ittmann, Michael ;

Spencer, David M. .

CANCER CELL, 2007, 12 (06) :559-571

[4] K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder [J].

Ahmad, Imran ;

Singh, Lukram Babloo ;

Foth, Mona ;

Morris, Carol-Ann ;

Taketo, Makoto Mark ;

Wu, Xue-Ru ;

Leung, Hing Y. ;

Sansom, Owen J. ;

Iwata, Tomoko .

DISEASE MODELS & MECHANISMS, 2011, 4 (04) :548-555

[5] Reduced Expression of Fibroblast Growth Factor Receptor 2IIIb in Hepatocellular Carcinoma Induces a More Aggressive Growth [J].

Amann, Thomas ;

Bataille, Frauke ;

Spruss, Thilo ;

Dettmer, Katja ;

Wild, Peter ;

Liedtke, Christian ;

Muehlbauer, Marcus ;

Kiefer, Paul ;

Oefner, Peter J. ;

Trautwein, Christian ;

Bosserhoff, Anja-Katrin ;

Hellerbrand, Claus .

AMERICAN JOURNAL OF PATHOLOGY, 2010, 176 (03) :1433-1442

[6] Analysis of fibroblast growth factor receptor 3 G697C mutation in oral squamous cell carcinomas [J].

Aubertin, Johannes ;

Tourpin, Sophie ;

Janot, Francois ;

Ahomadegbe, Jean-Charles ;

Radvanyi, Francois .

INTERNATIONAL JOURNAL OF CANCER, 2007, 120 (09) :2058-2059

[7] GP369, an FGFR2-IIIb-Specific Antibody, Exhibits Potent Antitumor Activity against Human Cancers Driven by Activated FGFR2 Signaling [J].

Bai, Ailin ;

Meetze, Kristan ;

Vo, Nhi Y. ;

Kollipara, Sriram ;

Mazsa, Elizabeth K. ;

Winston, William M. ;

Weiler, Solly ;

Poling, Laura L. ;

Chen, Ting ;

Ismail, Nesreen S. ;

Jiang, Jinwei ;

Lerner, Lorena ;

Gyuris, Jeno ;

Weng, Zhigang .

CANCER RESEARCH, 2010, 70 (19) :7630-7639

[8]

Bange J, 2002, CANCER RES, V62, P840

[9] The FGF family: biology, pathophysiology and therapy [J].

Beenken, Andrew ;

Mohammadi, Moosa .

NATURE REVIEWS DRUG DISCOVERY, 2009, 8 (03) :235-253

[10] Transcriptional profiling of mammary gland side population cells [J].

Behbod, Fariba ;

Xian, Wa ;

Shaw, Chad A. ;

Hilsenbeck, Susan G. ;

Tsimelzon, Anna ;

Rosen, Jeffrey M. .

STEM CELLS, 2006, 24 (04) :1065-1074

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