Role of Fcγ receptors in the pathogenesis and treatment of idiopathic thrombocytopenic purpura

被引：52
|
作者：
Crow, AR
Lazarus, AH
机构：
[1] St Michaels Hosp, Dept Lab Med & Pathobiol, Toronto, ON M5B 1W8, Canada
[2] Canadian Red Cross Blood Transfus Serv, Toronto, ON, Canada
[3] Toronto Platelet Immunobiol Grp, Toronto, ON, Canada
来源：
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2003年 / 25卷
关键词：
idiopathic thrombocytopenic purpura; intravenous immunoglobulin; Fc gamma receptors; platelets; phagocytosis;
D O I：
10.1097/00043426-200312001-00004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disease characterized by autoantibody-mediated platelet destruction. Platelets with associated IgG are targeted for destruction by phagocytic cells bearing Fc receptors in the reticuloendothelial system. While there are a variety of therapeutics available for this incompletely understood disease, one of the treatments of choice is infusion of intravenous immunoglobulin (IVIG). This review will discuss the pathophysiology of ITP with an emphasis on the role of Fcgamma receptors in both the pathogenesis and treatment of the disease by IVIG. Other prominent theories of the mechanisms of action of IVIG, including the role of anti-idiotype antibodies, will also be addressed.
引用
收藏
页码：S14 / S18
页数：5
相关论文
共 50 条
  • [1] The Role of Autoreactive T-cells in the Pathogenesis of Idiopathic Thrombocytopenic Purpura
    Masataka Kuwana
    Yasuo Ikeda
    International Journal of Hematology, 2005, 81 : 106 - 112
  • [2] The role of autoreactive T-cells in the pathogenesis of idiopathic thrombocytopenic purpura
    Kuwana, M
    Ikeda, Y
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2005, 81 (02) : 106 - 112
  • [3] Chronic Idiopathic Thrombocytopenic Purpura: Mechanisms of Pathogenesis
    Gernsheimer, Terry
    ONCOLOGIST, 2009, 14 (01) : 12 - 21
  • [4] Idiopathic thrombocytopenic purpura
    Kayal, L.
    Jayachandran, S.
    Singh, Khushboo
    CONTEMPORARY CLINICAL DENTISTRY, 2014, 5 (03) : 410 - 414
  • [5] IMPLICATION OF HUMAN FC RECEPTORS POLYMORPHISM IN CHILDHOOD IMMUNE THROMBOCYTOPENIC PURPURA
    Starcea, Iuliana Magdalena
    Rosu, V. E.
    Ivanov, Anca Viorica
    Mirou, Ingrith Crenguta
    Popescu, Roxana
    Antoci, L. M.
    Ciobanu, C. G.
    Spoiala, Elena-Lia
    Lupu, V. V.
    Rosu, Solange Tamara
    Alecsa, Mirabela-Smaranda
    Rusu, Carmen Daniela
    Lupu, Ancuta
    Gavrilovici, Cristina
    MEDICAL-SURGICAL JOURNAL-REVISTA MEDICO-CHIRURGICALA, 2023, 127 (02): : 260 - 274
  • [6] Idiopathic thrombocytopenic purpura: pathogenesis and potential therapeutic approach
    Zhao, Xiaohong
    Qi, Xiaomei
    Wang, Chen
    Zhou, Zhonghao
    Cao, Haiwu
    Wu, Pin
    Li, Linghao
    Lu, Shiyun
    Wang, Zhi
    MINERVA MEDICA, 2017, 108 (06) : 502 - 506
  • [7] Eltrombopag for the treatment of idiopathic thrombocytopenic purpura
    Stasi, Roberto
    EXPERT REVIEW OF HEMATOLOGY, 2008, 1 (02) : 145 - 152
  • [8] Does Helicobacter pylori play a role in the pathogenesis of childhood chronic idiopathic thrombocytopenic purpura?
    Maghbool, Maryam
    Maghbool, Masood
    Shahriari, Mehdi
    Karimi, Mehran
    PEDIATRIC REPORTS, 2009, 1 (01) : 11 - 13
  • [9] IDIOPATHIC THROMBOCYTOPENIC PURPURA
    TAILLAN, B
    HASTIER, P
    FERRARI, E
    FUZIBET, JG
    GRATECOS, N
    VINTI, H
    PESCE, A
    DUJARDIN, P
    PRESSE MEDICALE, 1991, 20 (34): : 1651 - 1654
  • [10] Idiopathic thrombocytopenic purpura
    Schroers, R.
    Duehrsen, U.
    DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 2007, 132 (08) : 383 - 390
12345