Inhibition of cyclooxygenase-2: a new targeted therapy for B-cell lymphoma?

被引：11
|
作者：
Phipps, RP
Ryan, E
Bernstein, SH
机构：
[1] Univ Rochester, Sch Med & Dent, Dept Environm Med & Dent, Lung Biol & Dis Program, Rochester, NY 14642 USA
[2] James P Wilmot Canc Ctr, Rochester, NY 14642 USA
来源：
LEUKEMIA RESEARCH | 2004年 / 28卷 / 02期
关键词：
cyclooxygenase-2; B-cell lymphoma; prostaglandin (PG);
D O I：
10.1016/S0145-2126(03)00260-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The purpose of this editorial is to highlight the findings reported herein in the paper by Wun et al. on the connection between expression of the cyclooxygenase-2 (COX-2) enzyme and B-cell lymphoma [Leuk. Res., in press]. We will first briefly review key aspects of the COX-2 enzyme, the newly discovered prostaglandin (PG) sypthases and their PG products, and their roles both in inflammation and in the pathogenesis of cancer. Having placed the COX pathway in this context, the discussion will then return to the provocative findings of Wun et al. [Leuk. Res., 28, 2004]. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：109 / 111
页数：3
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