Role of Chemotherapy in the Neoadjuvant/Adjuvant Setting for Patients With Rectal Adenocarcinoma Undergoing Chemoradiotherapy and Surgery or Radiotherapy and Surgery

被引：10

作者：

Ahmed, Shahab ^{[1
]}

Eng, Cathy ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, 1515 Holcombe Blvd,Unit 426, Houston, TX 77030 USA

来源：

CURRENT ONCOLOGY REPORTS | 2018年 / 20卷 / 01期

关键词：

Colorectal cancer; Rectal cancer; Locally advanced rectal cancer; Neoadjuvant chemoradiation; Adjuvant therapy; RANDOMIZED PHASE-III; TOTAL MESORECTAL EXCISION; PREOPERATIVE RADIOTHERAPY; ADJUVANT CHEMOTHERAPY; INDUCTION CHEMOTHERAPY; FOLLOW-UP; CANCER; CHEMORADIATION; TRIAL; FLUOROURACIL;

D O I：

10.1007/s11912-018-0652-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Rectal cancer has been successfully managed in the last couple of decades. In the USA, as the initial approach, neoadjuvant concurrent chemoradiation has been associated not only with decrease in tumor size and recurrence but also with higher resection rate with minimal side effects. Data support that addition of chemotherapy to radiotherapy is superior to radiotherapy alone in the neoadjuvant setting. Recent debates have addressed the question of administration of adjuvant chemotherapy following surgery. In this article, we discuss the role of chemotherapy in both the neoadjuvant and the adjuvant settings for locally advanced rectal cancer.

引用

页数：4

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