Helicobacter pylori Infection and Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

被引：22

作者：

Heydari, Keyvan ^{[1
,2
]}

Yousefi, Mohammad ^{[3
]}

Alizadeh-Navaei, Reza ^{[2
]}

Lotfi, Parisa ^{[1
]}

Sheydaee, Fateme ^{[3
]}

Raei, Maedeh ^{[4
]}

Vahdatinia, Alireza ^{[1
]}

Hessami, Amirhossein ^{[1
]}

Rafati, Sajjad ^{[1
]}

Moosazadeh, Mahmood ^{[2
]}

Ghasemian, Roya ^{[5
]}

Salehi, Fatemeh ^{[6
]}

Massoudi, Haleh ^{[7
]}

Ghaffari-Saravi, Fatemeh ^{[8
]}

Rismantab, Sahar ^{[7
]}

机构：

[1] Mazandaran Univ Med Sci, Fac Med, Student Res Comm, Sari, Iran

[2] Mazandaran Univ Med Sci, Gastrointestinal Canc Res Ctr, Noncommunicable Dis Inst, Sari, Iran

[3] Semnan Univ Med Sci, Dept Med, Fac Med, Semnan, Iran

[4] Islamic Azad Univ, Fac Med, Sari Branch, Sari, Iran

[5] Mazandaran Univ Med Sci, Antimicrobial Resistance Res Ctr, Dept Infect Dis, Sari, Iran

[6] Islamic Azad Univ, Dept Pathol, Sari Branch, Fac Med, Sari, Iran

[7] Mazandaran Univ Med Sci, Ramsar Campus, Ramsar, Iran

[8] Mazandaran Univ Med Sci, Tradit & Complementary Med Res Ctr, Addict Inst, Sari, Iran

来源：

TURKISH JOURNAL OF GASTROENTEROLOGY | 2022年 / 33卷 / 03期

关键词：

Fatty liver; Helicobacter; meta-analysis; steatohepatitis; NONALCOHOLIC STEATOHEPATITIS; HEPATIC-FIBROSIS; PREVALENCE; NAFLD;

D O I：

10.5152/tjg.2022.21467

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Since numerous studies have stated that there may be a relationship between Helicobacter pylon infection and nonalcoholic fatty liver disease and because of the high prevalence of both conditions worldwide, this study investigated the risk of non-alcoholic fatty liver in patients liver disease in patients infected with H. pylon. Following a systematic review of PubMed, Scopus, Web of Science and Embase, and a search in Google Scholar using MeSH terms such as H. pylon and non-alcoholic fatty liver disease, the relevant papers up to November 2020 were reviewed. All cohort, case-control, and cross-sectional studies that examined the risk of developing non-alcoholic fatty liver disease in patients infected with H. pylori entered this study. A meta-analysis was conducted in STATA 11. This systematic review examined 22 papers with 117 117 participants (33 711 patients infected with H pylori and 83 406 participants as control) and 20 studies were subjected to meta-analysis The results indicated a 22% to 27% increase in the risk of developing non-alcoholic fatty liver disease in patients infected with H. pylori (crude odds ratio: 1.27, 95% CI 1.17-1.33; and adjusted odds ratio: 1.22, 95% CI: 1.09-1.35). According to the subgroup analysis, the study region, sample size, and the method of diagnosing H. pylori were the factors contributing to the high heterogeneity. The meta-analysis revealed the increased risk of developing non-alcoholic fatty liver disease in patients infected with H. pylon TI is indicates that H. pylori is a serious risk factor in patients susceptible to NAFLD.

引用

页码：171 / 181

页数：11

共 50 条

[1] Helicobacter pylori as an Initiating Factor of Complications in Patients With Cirrhosis: A Single-Center Observational Study [J].