Demystifying the mechanism of action of professional facial peeling: In-vivo visualization and quantification of changes in inflammation, melanin and collagen using Vivascope® and ConfoScan®

被引:2
作者
Razi, Shazli [1 ]
Bhardwaj, Vinay [2 ]
Ouellette, Samantha [1 ,3 ]
Khan, Samavia [1 ,3 ]
Azadegan, Chloe [2 ,4 ]
Boyd, Thomas [2 ]
Rao, Babar [1 ,3 ]
机构
[1] Rao Dermatol, Dept Dermatol & Pathol, 95 First Ave, Atlantic Highlands, NJ 07716 USA
[2] Colgate Palmol, Dept Global Personal Care & Skin Hlth R&D, Piscataway, NJ USA
[3] Rutgers State Univ, Robert Wood Johnson Med Ctr, New Brunswick, NJ USA
[4] Sch Arts & Sci, Cell Biol & Neurosci, New Brunswick, NJ USA
关键词
collagen remodeling; exfoliation; melanin redistribution; peeling; professional peel; reflectance confocal microscopy; Vivascope; SKIN; RATIONALE; ALPHA;
D O I
10.1111/dth.15846
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Professional peeling using chemicals (chemical peeling) is a popular non-surgical procedure commonly used for the treatment for photoaging, pigmentary disorders, scarring, fine lines, and wrinkles. The objective of our case study was to elucidate the mechanism of action of professional peels/peeling. For proof-of-concept, we used a commercial blended peel containing trichloroacetic acid and lactic acid. The facial peeling was performed by a physician on four subjects. These subjects were followed over time in the clinic to take clinical pictures and monitor surface and anatomical changes in inflammation, melanin, and collagen at regular intervals post-peel (5 min, 48 h, and day 9). Dermoscope and Vivascope (R) were used to image surface and subsurface anatomical changes, respectively, and ConfoScan (R) was used to quantify aforementioned anatomical changes. Based on Vivascope and ConfoScan analysis, we could see clear visual clinical evidence of controlled injury-healing mechanism of peel's action: immediate but transient onset of inflammation within 5 min (indicate injury response by skin), followed by melanin redistribution evident at 48 h (indicate activation of skin's defense system), and remodeled fibrous collagen network without any inflammatory cells on day 9 (healing response). To our knowledge, this is the first ever clinical study to deconvolute the mysterious mechanism of action of peels, in-vivo.
引用
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页数:9
相关论文
共 13 条
[1]   Professional-Grade TCA-Lactic Acid Chemical Peel: Elucidating Mode of Action to Treat Photoaging and Hyperpigmentation [J].
Bhardwaj, Vinay ;
Sharma, Krati ;
Maksimovic, Srdjan ;
Fan, Aixing ;
Adams-Woodford, Alison ;
Mao, Junhong .
FRONTIERS IN MEDICINE, 2021, 8
[2]  
Briden ME, 2004, CUTIS, V73, P18
[3]   Quantitative and qualitative effects of chemical peeling on photo-aged skin: An experimental study [J].
Butler, PEM ;
Gonzalez, S ;
Randolph, MA ;
Kim, J ;
Kollias, N ;
Yaremchuk, MJ .
PLASTIC AND RECONSTRUCTIVE SURGERY, 2001, 107 (01) :222-228
[4]  
Goberdhan LT, 2013, J DRUGS DERMATOL, V12, pS38
[5]   An explanation for the mysterious distribution of melanin in human skin: a rare example of asymmetric (melanin) organelle distribution during mitosis of basal layer progenitor keratinocytes [J].
Joly-Tonetti, N. ;
Wibawa, J. I. D. ;
Bell, M. ;
Tobin, D. J. .
BRITISH JOURNAL OF DERMATOLOGY, 2018, 179 (05) :1115-1126
[6]  
Khater, 2014, J CLIN EXP DERMATOL, V5, P1
[7]   Comparative study of 15% trichloroacetic acid peel combined with 70% glycolic acid and 35% trichloroacetic acid peel for the treatment of photodamaged facial skin in aging women [J].
Kubiak, Marlena ;
Mucha, Paulina ;
Rotsztejn, Helena .
JOURNAL OF COSMETIC DERMATOLOGY, 2020, 19 (01) :137-146
[8]   Chemical peels: A review of current practice [J].
O'Connor, Alicia A. ;
Lowe, Patricia M. ;
Shumack, Stephen ;
Lim, Adrian C. .
AUSTRALASIAN JOURNAL OF DERMATOLOGY, 2018, 59 (03) :171-181
[9]  
Sadick N, 2019, J DRUGS DERMATOL, V18, P918
[10]  
Salvador, 2017, REFLECTANCE CONFOCAL