Long-range 1H-1H NMR correlation:: extending connectivities to remote bonds via an intermediate heterospin

被引：3

作者：

Parella, Teodor ^{[1
]}

Espinosa, Juan Felix ^{[2
]}

机构：

[1] Univ Autonoma Barcelona, Serv Ressonancia Magnet Nucl, E-08193 Barcelona, Spain

[2] Ctr Invest Lilly SA, Madrid, Spain

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 2008年 / 46卷 / 05期

关键词：

H-1; C-13; NMR spectroscopy; HMBC; H(C)H experiment; long-range correlation;

D O I：

10.1002/mrc.2200

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An out-and-stay 2D proton-proton NMR correlation experiment is proposed to detect long-range proton-proton connectivities up to six and seven bonds away. The magnetization flow pathway is based on a consecutive, dual-step J(CH)-transfer mechanism and it allows one to trace out H-1-H-1 connectivities between protons belonging to different spin systems. This novel experimental scheme will be particularly useful in cases when carbon resonances overlap, providing connectivity information that could not be obtained in a HMBC experiment. The success of the experiment is demonstrated in the structural studies of a wide variety of chemical compounds. Copyright (C) 2008 John Wiley & Sons, Ltd.

引用

页码：464 / 470

页数：7

共 33 条

[1] LONG-RANGE H-1-H-1 SPIN SPIN COUPLINGS THROUGH INTERGLYCOSIDIC OXYGEN AND THE PRIMARY STRUCTURE OF OLIGOSACCHARIDES AS STUDIED BY 2D-NMR [J].

BATTA, G ;

LIPTAK, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (01) :248-250

[2] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR [J].

BAX, A ;

SUMMERS, MF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (08) :2093-2094

[3] Long-range carbon-carbon connectivity via unsymmetrical indirect covariance processing of HSQC and HMBC NMR data [J].

Blinov, KA ;

Larin, NI ;

Williams, AJ ;

Zell, M ;

Martin, GE .

MAGNETIC RESONANCE IN CHEMISTRY, 2006, 44 (02) :107-109

[4] Unsymmetrical covariance processing of COSY or TOCSY and HSQC NMR data to obtain the equivalent of HSQC-COSY or HSQC-TOCSY spectra [J].

Blinov, KA ;

Larin, NI ;

Williams, AJ ;

Mills, KA ;

Martin, GE .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2006, 43 (01) :163-166

[5] Analysis and elimination of artifacts in indirect covariance NMR spectra via unsymmetrical processing [J].

Blinov, KA ;

Larin, NI ;

Kvasha, MP ;

Moser, A ;

Williams, AJ ;

Martin, GE .

MAGNETIC RESONANCE IN CHEMISTRY, 2005, 43 (12) :999-1007

[6] The use of unsymmetrical indirect covariance NMR methods to obtain the equivalent of HSQC-NOESY data [J].

Blinov, Kirill A. ;

Williams, Antony J. ;

Hilton, Bruce D. ;

Irish, Patrick A. ;

Martin, Gary E. .

MAGNETIC RESONANCE IN CHEMISTRY, 2007, 45 (07) :544-546

[7] COHERENCE TRANSFER BY ISOTROPIC MIXING - APPLICATION TO PROTON CORRELATION SPECTROSCOPY [J].

BRAUNSCHWEILER, L ;

ERNST, RR .

JOURNAL OF MAGNETIC RESONANCE, 1983, 53 (03) :521-528

[8] Sensitivity optimized HCN and HCNCH experiments for 13C/15N labeled oligonucleotides [J].

Fiala, R ;

Jiang, F ;

Sklenái, V .

JOURNAL OF BIOMOLECULAR NMR, 1998, 12 (03) :373-383

[9]

Hadden CE, 2000, MAGN RESON CHEM, V38, P143, DOI 10.1002/(SICI)1097-458X(200002)38:2<143::AID-MRC624>3.0.CO

[10]

2-S

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