Telomeres and Cancer

被引：29

作者：

Fan, Hueng-Chuen ^{[1
,2
,3
,4
]}

Chang, Fung-Wei ^{[5
]}

Tsai, Jeng-Dau ^{[6
,7
]}

Lin, Kao-Min

Chen, Chuan-Mu ^{[4
,8
]}

Lin, Shinn-Zong ^{[9
,10
,11
]}

Liu, Ching-Ann ^{[9
,10
,12
]}

Harn, Horng-Jyh ^{[9
,10
,13
,14
,15
]}

机构：

[1] Tungs Taichung Metroharbor Hosp, Dept Pediat, Taichung 435, Taiwan

[2] Tungs Taichung Metroharbor Hosp, Dept Med Res, Taichung 435, Taiwan

[3] JenTeh Jr Coll Med Nursing & Management, Dept Rehabil, Miaoli 356, Taiwan

[4] Natl Chung Hsing Univ, Agr Biotechnol Ctr, Dept Life Sci, Taichung 402, Taiwan

[5] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Obstet & Gynecol, Taipei 11490, Taiwan

[6] Chung Shan Med Univ, Sch Med, Taichung 402, Taiwan

[7] Chung Shan Med Univ Hosp, Dept Pediat, Taichung 402, Taiwan

[8] Fujian Med Univ, Xiamen Human Hosp, Dept Funct Neurosurg, Xiamen 361015, Peoples R China

[9] Natl Chung Hsing Univ, Rong Hsing Res Ctr Translat Med, IEGG & Anim Biotechnol Ctr, Taichung 402, Taiwan

[10] Tzu Chi Fdn, Buddhist Tzu Chi Bioinnovat Ctr, Hualien 970, Taiwan

[11] Buddhist Tzu Chi Med Fdn, Bioinnovat Ctr, Hualien 970, Taiwan

[12] Buddhist Tzu Chi Gen Hosp, Dept Neurosurg, Hualien 970, Taiwan

[13] Hualien Tzu Chi Hosp, Dept Med Res, Hualien 970, Taiwan

[14] Tzu Chi Univ, Dept Pathol, Hualien 970, Taiwan

[15] Tzu Chi Univ, Buddhist Tzu Chi Gen Hosp, Dept Pathol, Hualien 970, Taiwan

来源：

LIFE-BASEL | 2021年 / 11卷 / 12期

关键词：

telomerase; telomerase reverse transcriptase; shelterin; CST; promoter mutations; REPLICATION PROTEIN-A; SINGLE-STRANDED-DNA; TERT PROMOTER MUTATIONS; REPEAT-CONTAINING RNA; WERNER-SYNDROME PROTEIN; MAINTENANCE COMPONENT 1; CELL LUNG-CANCER; HUMAN CST; DAMAGE RESPONSE; BINDING PROTEIN;

D O I：

10.3390/life11121405

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Telomeres cap the ends of eukaryotic chromosomes and are indispensable chromatin structures for genome protection and replication. Telomere length maintenance has been attributed to several functional modulators, including telomerase, the shelterin complex, and the CST complex, synergizing with DNA replication, repair, and the RNA metabolism pathway components. As dysfunctional telomere maintenance and telomerase activation are associated with several human diseases, including cancer, the molecular mechanisms behind telomere length regulation and protection need particular emphasis. Cancer cells exhibit telomerase activation, enabling replicative immortality. Telomerase reverse transcriptase (TERT) activation is involved in cancer development through diverse activities other than mediating telomere elongation. This review describes the telomere functions, the role of functional modulators, the implications in cancer development, and the future therapeutic opportunities.

引用

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