Design, Synthesis, and Anticancer Activity of Some New N-{5-[(1H-Benzo[d]imidazol-1-yl)methyl]isoxazol-3-yl}benzamide Hybrids

被引：1

作者：

Pandiri, Madhuri ^{[1
]}

Nukala, Satheesh Kumar ^{[1
]}

Swamy, Thirukovela Narsimha ^{[1
]}

Dasari, Gouthami ^{[1
]}

Badithapuram, Vinitha ^{[1
]}

Manchal, Ravinder ^{[1
]}

Bandari, Srinivas ^{[1
]}

机构：

[1] Chaitanya Deemed Univ, Dept Chem, Warangal 506001, Andhra Pradesh, India

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2021年 / 91卷 / 11期

关键词：

benzimidazole; isoxazole; amide; anti-cancer activity;

D O I：

10.1134/S1070363221110207

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis of some new N-{5-[(1H-benzo[d]imidazol-1-yl)methyl]isoxazol-3-yl}benzamide hybrids is presented herein. The in vitro anti-cancer activity of the synthesized compounds against four human cancer cell lines A549 (lung), HeLa (cervical), IMR-32 (neuroblast), and HEK-293 (embryonic kidney) has been tested. Four products have been determined to be active against all the cell lines. The compound N-{5-[(1H-benzo[d]imidazol-1-yl)methyl]isoxazol-3-yl}-3,5-dimethoxybenzamide has been characterized by significant anti-proliferative efficiency towards all tested cancer cells compared to the standard.

引用

页码：2320 / 2326

页数：7

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