WASP family proteins: Molecular mechanisms and implications in human disease

被引：26
作者：
Kramer, Daniel A. [1 ]
Piper, Hannah K. [1 ]
Chen, Baoyu [1 ]
机构：
[1] Iowa State Univ, Roy J Carver Dept Biochem Biophys & Mol Biol, 2437 Pammel Dr, Ames, IA 50011 USA
来源：
EUROPEAN JOURNAL OF CELL BIOLOGY | 2022年 / 101卷 / 03期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
Wiskott-Aldrich syndrome; WASP; WAVE; WRC; WASH; SHRC; WHAMM; JMY; WHIMP; Arp2; 3; Actin; VCA; WCA; Sra1; Cyfip; SCAR; HEM; Strumpellin; SWIP; WISKOTT-ALDRICH-SYNDROME; WAVE REGULATORY COMPLEX; ENTEROPATHOGENIC ESCHERICHIA-COLI; FOCAL ADHESION KINASE; RECESSIVE INTELLECTUAL DISABILITY; ACTIN-DEPOLYMERIZING PROTEIN; N-WASP; ARP2/3; COMPLEX; BREAST-CANCER; CELL-MIGRATION;
D O I：
10.1016/j.ejcb.2022.151244
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Proteins of the Wiskott-Aldrich syndrome protein (WASP) family play a central role in regulating actin cytoskeletal dynamics in a wide range of cellular processes. Genetic mutations or misregulation of these proteins are tightly associated with many diseases. The WASP-family proteins act by transmitting various upstream signals to their conserved WH2-Central-Acidic (WCA) peptide sequence at the C-terminus, which in turn binds to the Arp2/ 3 complex to stimulate the formation of branched actin networks at membranes. Despite this common feature, the regulatory mechanisms and cellular functions of distinct WASP-family proteins are very different. Here, we summarize and clarify our current understanding of WASP-family proteins and how disruption of their functions is related to human disease.
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页数：28
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