Human Organ-Specific 3D Cancer Models Produced by the Stromal Self-Assembly Method of Tissue Engineering for the Study of Solid Tumors

被引:32
作者
Roy, Vincent [1 ,2 ]
Magne, Brice [1 ,2 ]
Vaillancourt-Audet, Maude [1 ,2 ]
Blais, Mathieu [1 ,2 ]
Chabaud, Stephane [1 ,2 ]
Grammond, Emil [1 ,2 ]
Piquet, Leo [1 ,2 ,3 ]
Fradette, Julie [1 ,2 ,4 ]
Laverdiere, Isabelle [3 ,5 ,6 ]
Moulin, Veronique J. [1 ,2 ,4 ]
Landreville, Solange [1 ,2 ,3 ,7 ]
Germain, Lucie [1 ,2 ,4 ]
Auger, Francois A. [1 ,2 ,4 ]
Gros-Louis, Francois [1 ,2 ,4 ]
Bolduc, Stephane [1 ,2 ,4 ]
机构
[1] Univ Laval, CHU Quebec, Ctr Rech, Axe Med Regneratice, Quebec City, PQ, Canada
[2] Univ Laval, LOEX, Ctr Rech Organogenese Expt, Quebec City, PQ, Canada
[3] Univ Laval, Ctr Rech Canc, Quebec City, PQ, Canada
[4] Univ Laval, Fac Med, Dept Surg, Quebec City, PQ, Canada
[5] Univ Laval, Fac Pharm, Quebec City, PQ, Canada
[6] Univ Laval, Res Ctr, CHU Quebec, Div Oncol, Quebec City, PQ, Canada
[7] Univ Laval, Fac Med, Dept Ophthalmol, Quebec City, PQ, Canada
关键词
BASAL-CELL CARCINOMA; NONMELANOMA SKIN-CANCER; HEPATIC STELLATE CELLS; IN-VITRO; EXTRACELLULAR-MATRIX; NEUROFIBROMATOSIS TYPE-1; UVEAL MELANOMA; 3-DIMENSIONAL CULTURE; MICROVASCULAR NETWORK; LYMPHATIC CAPILLARIES;
D O I
10.1155/2020/6051210
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Cancer research has considerably progressed with the improvement of in vitro study models, helping to understand the key role of the tumor microenvironment in cancer development and progression. Over the last few years, complex 3D human cell culture systems have gained much popularity over in vivo models, as they accurately mimic the tumor microenvironment and allow high-throughput drug screening. Of particular interest, in vitrohuman 3D tissue constructs, produced by the self-assembly method of tissue engineering, have been successfully used to model the tumor microenvironment and now represent a very promising approach to further develop diverse cancer models. In this review, we describe the importance of the tumor microenvironment and present the existing in vitro cancer models generated through the self-assembly method of tissue engineering. Lastly, we highlight the relevance of this approach to mimic various and complex tumors, including basal cell carcinoma, cutaneous neurofibroma, skin melanoma, bladder cancer, and uveal melanoma.
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页数:23
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共 251 条
  • [1] The evolution of tenascins and fibronectin
    Adams, Josephine C.
    Chiquet-Ehrismann, Ruth
    Tucker, Richard P.
    [J]. CELL ADHESION & MIGRATION, 2015, 9 (1-2) : 22 - 33
  • [2] Comparative Analysis of 3D Bladder Tumor Spheroids Obtained by Forced Floating and Hanging Drop Methods for Drug Screening
    Amaral, Robson L. F.
    Miranda, Mariza
    Marcato, Priscyla D.
    Swiech, Kamilla
    [J]. FRONTIERS IN PHYSIOLOGY, 2017, 8
  • [3] [Anonymous], NEW ENGLAND J MED
  • [4] [Anonymous], ERNST SCHER RES FDN
  • [5] [Anonymous], NEUROLOGY
  • [6] Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment
    Aponte, Pedro M.
    Caicedo, Andres
    [J]. STEM CELLS INTERNATIONAL, 2017, 2017
  • [7] Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice
    Aszterbaum, M
    Epstein, J
    Oro, A
    Douglas, V
    LeBoit, PE
    Scott, MP
    Epstein, EH
    [J]. NATURE MEDICINE, 1999, 5 (11) : 1285 - 1291
  • [8] Auepemkiate S, 2002, HISTOPATHOLOGY, V40, P568, DOI 10.1046/j.1365-2559.2002.01393.x
  • [9] Role of seaweed laminaran from Saccharina longicruris on matrix deposition during dermal tissue-engineered production
    Ayoub, Akram
    Pereira, Jadson Moreira
    Rioux, Laurie-Eve
    Turgeon, Sylvie L.
    Beaulieu, Martin
    Moulin, Veronique J.
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2015, 75 : 13 - 20
  • [10] The bidirectional crosstalk between metastatic uveal melanoma cells and hepatic stellate cells engenders an inflammatory microenvironment
    Babchia, Narjes
    Landreville, Solange
    Clement, Bruno
    Coulouarn, Cedric
    Mouriaux, Frederic
    [J]. EXPERIMENTAL EYE RESEARCH, 2019, 181 : 213 - 222