Palladium-Catalyzed Direct Cross-Coupling Reaction of Glycals with Activated Alkenes

被引：54

作者：

Bai, Yaguang ^{[1
]}

Zeng, Jing ^{[1
]}

Cai, Shuting ^{[1
]}

Liu, Xue-Wei ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Singapore 637371, Singapore

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 16期

关键词：

DIELS-ALDER REACTIONS; MECHANISTIC INSIGHTS; READY ACCESS; AZIRIDINATION; ACRYLATES; ETHERS; CORE;

D O I：

10.1021/ol201734w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for a Pd(OAc)(2)-catalyzed cross-coupling reaction of glycals with activated alkenes under mild conditions has been developed. This transformation provides an expedient synthetic method to C(2)-functionalized glycals, which are common structural building blocks In natural products and other biologically active compounds. The reaction scope Includes different kinds of carbohydrates, protecting groups and substituents on alkene. Moderate to excellent yields and pure E configuration selectivity were obtained.

引用

页码：4394 / 4397

页数：4

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