Risk of Malignant Neoplasm of the Pancreas in Relation to Diabetes A population-based study in Taiwan

被引：35

作者：

Chen, Hua-Fen ^{[2
,3
]}

Chen, Peter ^{[4
]}

Li, Chung-Yi ^{[1
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med, Dept Publ Hlth, Tainan 70101, Taiwan

[2] Far Eastern Mem Hosp, Dept Endocrinol, Taipei Cty, Taiwan

[3] Fujen Catholic Univ, Sch Med, Taipei Cty, Taiwan

[4] Cent Med Hosp Grp, Dept Gastroenterol, Taipei Cty, Taiwan

来源：

DIABETES CARE | 2011年 / 34卷 / 05期

关键词：

CIGARETTE-SMOKING; CANCER; MELLITUS; ENDOCRINE; COHORT;

D O I：

10.2337/dc10-2006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE-We prospectively assessed the age- and sex-specific incidence and relative risk of malignant neoplasm of the pancreas in Taiwan's diabetic population. RESEARCH DESIGN AND METHODS-A total of 615,532 diabetic patients and 614,871 age- and sex-matched control subjects were linked to inpatient claims (2000-2006) to identify the admissions for malignant neoplasm of the pancreas (ICD-9: 157). The Cox proportional hazards regression model was used to estimate the age- and sex-specific relative risk of pancreatic neoplasm. RESULTS-Compared with the control group, the diabetic patients had a significantly increased risk of pancreatic cancer (hazard ratio [HR] 1.54 [95% CI 1.39-1.71]). The higher and significant age-specific HRs were observed in diabetic men (1.91) and women (1.80) aged 45-65 years. CONCLUSIONS-Middle-aged diabetic men and women were associated with the most increased risk of malignant neoplasm of the pancreas.

引用

页码：1177 / 1179

页数：3

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