Solubilities of Pharmaceutical Compounds in Ionic Liquids

被引：95
|
作者：
Smith, K. B. [1 ,2 ]
Bridson, R. H. [1 ]
Leeke, G. A. [1 ]
机构：
[1] Univ Birmingham, Sch Chem Engn, Birmingham B15 2TT, W Midlands, England
[2] GlaxoSmithKline, Harlow CM19 5AW, Essex, England
来源：
JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2011年 / 56卷 / 05期
关键词：
PARACETAMOL; CRYSTALLIZATION; ACETAMINOPHEN; MICROEMULSION; LYSOZYME;
D O I：
10.1021/je101040p
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
The solubilities of paracetamol and ibuprofen were determined in two different ionic liquids at temperatures of 298.15 K, 308.15 K, 318.15 K, 328.15 K, and 338.15 K. The ionic liquids selected were 1-butyl-3-methylimidazolium hexafluorophosphate [BMIM][PF6] and 1-hexyl-3-methylimidazolium hexafluorophosphate [HMIM][PF6]. In addition, solubility data for paracetamol and ibuprofen in water are reported at the same temperatures extending the data commonly reported in pharmaceutical reference texts. For all solvents the concentration of drug in solution was determined by UV spectrophotometry.
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收藏
页码：2039 / 2043
页数：5
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