Femtosecond laser treatment promotes the surface bioactivity and bone ingrowth of Ti6Al4V bone scaffolds

被引：11

作者：

Wang, Su ^{[1
]}

Zhang, Miao ^{[1
]}

Liu, Linlin ^{[1
]}

Xu, Rongwei ^{[1
]}

Huang, Zhili ^{[1
]}

Shi, Zhang'ao ^{[1
]}

Liu, Juncai ^{[2
]}

Li, Zhong ^{[2
]}

Li, Xiaohong ^{[3
]}

Hao, Peng ^{[4
]}

Hao, Yongqiang ^{[5
]}

机构：

[1] Sichuan Univ, Sch Mech Engn, Chengdu, Peoples R China

[2] Southwest Med Univ, Affiliated Hosp, Dept Orthopaed, Sichuan Prov Lab Orthoped Engn, Luzhou, Peoples R China

[3] Southwest Univ Sci & Technol, Sch Sci, Mianyang, Peoples R China

[4] Sichuan Prov Peoples Hosp, Chengdu, Peoples R China

[5] Shanghai Jiao Tong Univ, Peoples Hosp 9, Sch Med, Dept Orthoped Surg, Shanghai, Peoples R China

来源：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2022年 / 10卷

基金：

国家重点研发计划;

关键词：

femtosecond laser; micro-nano surface morphology; super hydrophilic structure; surface bioactivity; bone tissue growth; TITANIUM SURFACES; OSTEOGENIC DIFFERENTIATION; TEXTURED TI-6AL-4V; IMPLANT; WETTABILITY; OSSEOINTEGRATION; OXIDATION; ALLOY;

D O I：

10.3389/fbioe.2022.962483

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In this study, a femtosecond laser with a wavelength of 800 nm was used to modify the surface of a titanium alloy bone scaffold created via selective laser melting (SLM). The outcomes demonstrated that the surface morphology of the bone scaffold after femtosecond laser treatment was micro-nano morphology. The hydrophobic structure of the scaffold was changed into a super-hydrophilic structure, improving the surface roughness, which was highly helpful for osteoblast adhesion and differentiation. The femtosecond laser surface treatment in vitro samples produced a thick layer of hydroxyapatite (HAP) with improved surface bioactivity. The effectiveness of osseointegration and interstitial growth of the specimens treated with the femtosecond laser surface were found to be better when bone scaffolds were implanted into the epiphysis of the tibia of rabbits. As a result, femtosecond laser therapy dramatically enhanced the surface activity of bone scaffolds and their capacity to integrate with the surrounding bone tissues, serving as a trustworthy benchmark for future biological scaffold research.

引用

页数：11

共 38 条

[1] Osseointegration and stability of a modified sand-blasted acid-etched implant: an experimental pilot study in sheep [J].