Interferon-gamma Inducible Protein 10-biomarker for treatment outcome in chronic hepatitis C

被引：0

作者：

Sultana, Camelia ^{[1
,2
]}

Oprisan, Gabriela ^{[3
]}

Grancea, Camelia ^{[2
]}

Teleman, Monica Delia ^{[4
]}

Oprea, Cristiana ^{[5
]}

Florescu, Simin ^{[5
]}

Dinu, Sorin ^{[3
]}

Ceausu, Emanoil ^{[5
]}

Ruta, Simona ^{[1
,2
]}

机构：

[1] Carol Davila Univ Med & Pharm, Virol Discipline, 8 Eroilor Sanit Bvd, Bucharest, Romania

[2] Stefan S Nicolau Inst Virol, Dept Emergent Viral Dis, 285 Mihai Bravu Bvd, Bucharest, Romania

[3] NIRDMI Cantacuzino, Mol Epidemiol Lab, 103 Splaiul Independentei Bvd, Bucharest, Romania

[4] Carol Davila Univ Med & Pharm, Dept Microbiol & Epidemiol, Bucharest, Romania

[5] Dr Victor Babes Clin Infect & Trop Dis, 281 Mihai Bravu Bvd, Bucharest, Romania

来源：

ROMANIAN BIOTECHNOLOGICAL LETTERS | 2017年 / 22卷 / 06期

关键词：

chronic hepatitis C; treatment; IP-10; sCD26; IL28B polymorphism; HCV INFECTION; FIBROSIS; PREDICTS; CXCL10; IL28B; INFLAMMATION; RNA;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The predictive value of two easy-to-determine serum biomarkers: IP-10 (Interferon-gamma inducible protein-10 kD) and sCD26 (soluble CD26) on the virological response of interferon-based therapy was assessed in 119 patients with chronic hepatitis C. Patients who obtained sustained virological response (SVR) had significantly decreased baseline IP-10 concentrations as compared to non-responders (mean IP-10 = 338 +/- 200 pg/mL vs. 472.7 +/- 254 g/mL; p=0.003). Correlation of this inexpensive serological marker with IL2B genotype and baseline HCV viral load can be used in the selection of patients who might benefit from interferon-based therapies, which are currently available in developing economies. On the contrary, there was no correlation between the baseline concentration of sCD26 and the outcome of treatment. IP-10 might be a suitable biomarker to predict virological success after pegylated interferon alpha and ribavirin treatment.

引用

页码：13155 / 13162

页数：8

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