Synthesis of NB-506, a new anticancer agent

被引：57

作者：

Ohkubo, M

Kawamoto, H

Ohno, T

Nakano, M

Morishima, H

机构：

[1] Banyu Tukuba Research Institute, Merck Research Laboratories, Tsukuba 300-33

来源：

TETRAHEDRON | 1997年 / 53卷 / 02期

关键词：

D O I：

10.1016/S0040-4020(96)01004-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

6-N-formylamino-12,13-dihydro-1,11-dihydroxy-13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (NB-506, 2), a derivative of the naturally occurring antitumor compound, BE-13793C (3), is a new indolopyrrolocarbazole anticancer agent which potently inhibits topoisomerase I. The synthesis of NB-506 was accomplished starting from dibromomaleimide 4 and indole compound 5. The key step, a glycosylation of indolocarbazole, was precisely studied to develop a practical synthesis method using KOH as a base. Copyright (C) 1996 Elsevier Science Ltd

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页码：585 / 592

页数：8

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