Could renin-angiotensin-aldosterone system activation explain the amputations associated with canagliflozin? The nitric oxide hypothesis

被引:4
作者
Leon Jimenez, David [1 ]
Lopez Chozas, Jose Manuel [2 ]
Espino Montoro, Antonio [2 ]
Rico Corral, Miguel Angel [1 ]
Castilla Guerra, Luis [1 ]
Miramontes Gonzalez, Jose Pablo [3 ]
机构
[1] Hosp Univ Virgen Macarena, Unidad Riesgo Vasc, Med Interna, Seville, Spain
[2] Hosp Univ Virgen del Rocio, Unidad Gest Clin Med Interna, Seville, Spain
[3] Hosp Univ Salamanca, Inst Invest Biomed Salamanca IBSAL, Med Interna, Salamanca, Spain
关键词
ENDOTHELIAL FUNCTION; DIABETES-MELLITUS; INHIBITION; BRADYKININ;
D O I
10.1016/j.diabres.2018.12.006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:10 / 13
页数:4
相关论文
共 24 条
[1]   Blood pressure-lowering effect of the sodium glucose co-transporter-2 inhibitor ertugliflozin, assessed via ambulatory blood pressure monitoring in patients with type 2 diabetes and hypertension [J].
Amin, N. B. ;
Wang, X. ;
Mitchell, J. R. ;
Lee, D. S. ;
Nucci, G. ;
Rusnak, J. M. .
DIABETES OBESITY & METABOLISM, 2015, 17 (08) :805-808
[2]  
[Anonymous], 2018, FDA ADVERSE EVENTS R
[3]   Possible role of bradykinin and angiotensin II in the regulation of penile erection and detumescence [J].
Becker, AJ ;
Ückert, S ;
Stief, CG ;
Truss, MC ;
Machtens, S ;
Scheller, F ;
Knapp, WH ;
Hartmann, U ;
Jonas, U .
UROLOGY, 2001, 57 (01) :193-198
[4]   Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion [J].
Calado, Joaquim ;
Sznajer, Yves ;
Metzger, Daniel ;
Rita, Ana ;
Hogan, Marie C. ;
Kattamis, Antonis ;
Scharf, Mauro ;
Tasic, Velibor ;
Greil, Johann ;
Brinkert, Florian ;
Kemper, Markus J. ;
Santer, Rene .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2008, 23 (12) :3874-3879
[5]   Sodium glucose cotransport-2 inhibition and intrarenal RAS activity in people with type 1 diabetes [J].
Cherney, David Z. I. ;
Perkins, Bruce A. ;
Soleymanlou, Nima ;
Xiao, Fengxia ;
Zimpelmann, Joseph ;
Woerle, Hans-Juergen ;
Johansen, Odd E. ;
Broedl, Uli C. ;
von Eynatten, Maximilian ;
Burns, Kevin D. .
KIDNEY INTERNATIONAL, 2014, 86 (05) :1057-1058
[6]   Renal Hemodynamic Effect of Sodium-Glucose Cotransporter 2 Inhibition in Patients With Type 1 Diabetes Mellitus [J].
Cherney, David Z. I. ;
Perkins, Bruce A. ;
Soleymanlou, Nima ;
Maione, Maria ;
Lai, Vesta ;
Lee, Alana ;
Fagan, Nora M. ;
Woerle, Hans J. ;
Johansen, Odd Erik ;
Broedl, Uli C. ;
von Eynatten, Maximilian .
CIRCULATION, 2014, 129 (05) :587-597
[7]   Hyperfiltration and effect of nitric oxide inhibition on renal and endothelial function in humans with uncomplicated type 1 diabetes mellitus [J].
Cherney, David Z. I. ;
Reich, Heather N. ;
Jiang, Shan ;
Har, Ronnie ;
Nasrallah, Rania ;
Hebert, Richard L. ;
Lai, Vesta ;
Scholey, James W. ;
Sochett, Etienne B. .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2012, 303 (07) :R710-R718
[8]   Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes [J].
Heerspink, H. J. Lambers ;
de Zeeuw, D. ;
Wie, L. ;
Leslie, B. ;
List, J. .
DIABETES OBESITY & METABOLISM, 2013, 15 (09) :853-862
[9]   Acute Pharmacodynamic Effects of Empagliflozin With and Without Diuretic Agents in Patients With Type 2 Diabetes Mellitus [J].
Heise, Tim ;
Jordan, Jens ;
Wanner, Christoph ;
Heer, Martina ;
Macha, Sreeraj ;
Mattheus, Michaela ;
Lund, Soren S. ;
Woerle, Hans J. ;
Broedl, Uli C. .
CLINICAL THERAPEUTICS, 2016, 38 (10) :2248-2264
[10]   Endothelial function and bradykinin in humans [J].
Hornig, B ;
Drexler, H .
DRUGS, 1997, 54 (Suppl 5) :42-47