Iron(III)-Catalyzed Conia-Ene Cyclization of 2-Alkynic 1,3-Dicarbonyl Compounds

被引：49

作者：

Chan, Li Yan ^{[1
]}

Kim, Sunggak ^{[1
]}

Park, Youngchul ^{[2
]}

Lee, Phil Ho ^{[2
]}

机构：

[1] Nanyang Technol Univ, Div Chem & Biol Chem, Sch Phys & Math Sci, Singapore 637371, Singapore

[2] Kangwon Natl Univ, Dept Chem, Chunchon 200701, South Korea

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

ONE-POT SYNTHESIS; COOPERATIVE CATALYSIS; BETA-KETOESTERS; EFFICIENT; IRON; ETHENETRICARBOXYLATES; CYCLOISOMERIZATION; CONSTRUCTION; ALCOHOLS; LIGANDS;

D O I：

10.1021/jo300957q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cheap, simple, and effective FeCl3-catalyzed Conia-ene cyclization of 2-alkynic 1,3-dicarbonyl compounds was stereospecific to afford alkylidenecyclopentanes in (E)-isomers via the 5-exo-dig pathway. The 5-endo-dig and 6-exo-dig cyclizations were also possible, depending on the structure of the substrates.

引用

页码：5239 / 5244

页数：6

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