Assessment of antiplatelet activity of 2-aminopyrimidines

被引：18

作者：

Giridhar, Rajani ^{[1
]}

Tamboli, Riyaj S. ^{[1
]}

Ramajayam, R. ^{[1
]}

Prajapati, Dhaval G. ^{[1
]}

Yadav, M. R. ^{[1
]}

机构：

[1] Maharaja Sayajirao Univ Baroda, Fac Engn & Technol, Dept Pharm, Vadodara 390001, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 50卷

关键词：

2-Aminopyrimidines; Aspirin; Thrombosis; Antiplatelet agents; RECEPTOR LIGANDS; INHIBITORS; SERIES; DERIVATIVES;

D O I：

10.1016/j.ejmech.2012.01.035

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 4,6-diaryl-2-aminopyrimidines was developed as antiplatelet agents and their potency was evaluated by in vitro assay. Compound 14k was found to be two times more potent than aspirin. These encouraging results could be helpful for the development of new antiplatelet compounds. (C) 2012 Elsevier Masson SAS. All rights reserved.

引用

页码：428 / 432

页数：5

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