Androgen regulation of axon growth and neurite extension in motoneurons

被引：43

作者：

Fargo, Keith N. ^{[1
,3
]}

Galbiati, Mariarita ^{[4
,5
,6
]}

Foecking, Eileen M. ^{[2
,3
]}

Poletti, Angelo ^{[4
,5
,6
]}

Jones, Kathryn J. ^{[2
,3
]}

机构：

[1] Loyola Univ Chicago, Stritch Sch Med, Dept Cell Biol Neurobiol & Anat, Maywood, IL 60153 USA

[2] Loyola Univ Chicago, Dept Otolaryngol, Maywood, IL 60153 USA

[3] Hines VA Hosp, Res & Dev Serv, Hines, IL USA

[4] Univ Milan, Ctr Excellence Neurodegenerat Dis, Inst Endocrinol, Milan, Italy

[5] Univ Florence, InterUniv Ctr Neurodegenerat Dis, Rome, Italy

[6] Univ Florence, InterUniv Ctr Neurodegenerat Dis, Milan, Italy

来源：

HORMONES AND BEHAVIOR | 2008年 / 53卷 / 05期

关键词：

androgens; motoneurons; peripheral nerve injury; spinal cord injury; motoneuron disease; gonadal steroids;

D O I：

10.1016/j.yhbeh.2008.01.014

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Androgens act on the CNS to affect motor function through interaction with a widespread distribution of intracellular androgen receptors (AR). This review highlights our work on androgens and process outgrowth in motoneurons, both in vitro and in vivo. The actions of androgens on motoneurons involve the generation of novel neuronal interactions that are mediated by the induction of androgen-dependent neurite or axonal outgrowth. Here, we summarize the experimental evidence for the androgenic regulation of the extension and regeneration of motoneuron neurites in vitro using cultured immortalized motoneurons, and axons in vivo using the hamster facial nerve crush paradigm. We place particular emphasis on the relevance of these effects to SBMA and peripheral nerve injuries. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：716 / 728

页数：13

共 132 条

[1] Spinobulbar muscular atrophy:: polyglutamine-expanded androgen receptor is proteolytically resistant in vitro and processed abnormally in transfected cells [J].