ZBTB1 is a determinant of lymphoid development

被引：38

作者：

Siggs, Owen M. ^{[1
]}

Li, Xiaohong ^{[1
]}

Xia, Yu ^{[1
]}

Beutler, Bruce ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Genet, La Jolla, CA 92037 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2012年 / 209卷 / 01期

基金：

美国国家卫生研究院; 比尔及梅琳达.盖茨基金会;

关键词：

ACUTE LYMPHOBLASTIC-LEUKEMIA; CELL DIFFERENTIATION; BONE-MARROW; TRANSCRIPTION; LINEAGE; COMMITMENT; NOTCH1; MICE; IDENTIFICATION; PROGENITORS;

D O I：

10.1084/jem.20112084

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, we describe a chemically induced mouse mutation that caused a complete and cell-intrinsic T cell deficiency. Development of other lymphoid lineages was also partially impaired and was severely compromised under competitive conditions. Positional cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing 1), a gene conserved throughout vertebrate evolution. Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator.

引用

页码：19 / 27

页数：9

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