Synthesis and Anticancer Activity of Indolin-2-one Derivatives Bearing the 4-Thiazolidinone Moiety

被引：36

作者：

Wang, Shuobing ^{[1
]}

Zhao, Yanfang ^{[1
]}

Zhu, Wufu ^{[1
]}

Liu, Ying ^{[1
]}

Guo, Kaixing ^{[1
]}

Gong, Ping ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Key Lab Original New Drugs Design & Discovery, Minist Educ, Shenyang 110016, Liaoning, Peoples R China

来源：

ARCHIV DER PHARMAZIE | 2012年 / 345卷 / 01期

关键词：

Anticancer activity; Indolin-2-one; 4-Thiazolidinone; ANTIPROLIFERATIVE ACTIVITY; CANCER CELLS; INHIBITORS; DISCOVERY; AGENTS; CYTOTOXICITY; RHODANINE; LEUKEMIA; DESIGN; GROWTH;

D O I：

10.1002/ardp.201100082

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of indolin-2-one derivatives containing the 4-thiazolidinone moiety (5a-5p) was synthesized and the cytotoxicity of these derivatives was evaluated in vitro against three human cancer cell lines (HT-29, H460 and MDA-MB-231) by standard MTT assay. Some prepared compounds exhibited significant cytotoxicity against different human cancer cell lines. Several potent compounds were further evaluated against one normal cell line (WI-38). In particular, the promising compound 5h showed remarkable cytotoxicity and selectivity against the HT-29 and H460 cancer cell lines (IC50 = 0.016 mu mol/L, 0.0037 mu mol/L, respectively).

引用

页码：73 / 80

页数：8

共 50 条

[41] Synthesis and antimicrobial screening of 4-thiazolidinone and 2-azetidinone derivatives of piperazine
Shingade, Sunil G.
Bari, Sanjaykumar B.
MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (02) : 699 - 706
[42] Synthesis and hypnotic activity of new 4-thiazolidinone and 2-thioxo-4,5-imidazolidinedione derivatives
Ergenç, N
Çapan, G
Günay, NS
Özkirimli, S
Güngör, M
Özbey, S
Kendi, E
ARCHIV DER PHARMAZIE, 1999, 332 (10) : 343 - 347
[43] On the antioxidant activity of ortho- and meta-substituted indolin-2-one derivatives
Meysam Najafi
Monatshefte für Chemie - Chemical Monthly, 2014, 145 : 291 - 299
[44] Synthesis, preliminary pharmacological evaluation, molecular docking, and ADME studies of new 4-thiazolidinone derivatives bearing ketoprofen moiety targeting cyclooxygenase enzyme
Allawi, Mustafa M.
Mahdi, Monther F.
Raauf, Ayad M. R.
EGYPTIAN JOURNAL OF CHEMISTRY, 2021, 64 (12): : 7239 - 7250
[45] Synthesis and receptor binding assay of indolin-2-one derivatives as dopamine D4 receptor ligands
Li Gu-Cai
Zhang Bian-Ling
Xia Jiao-Yun
Fang Zheng-Jun
PHARMAZIE, 2015, 70 (08): : 511 - 514
[46] Synthesis, characterization and anticancer activity of certain 3-{4-(5-mercapto-1,3,4-oxadiazole-2-yl) phenylimino}indolin-2-one derivatives
Gudipati, Rajyalakshmi
Anreddy, Rama Narsimha Reddy
Manda, Sarangapani
SAUDI PHARMACEUTICAL JOURNAL, 2011, 19 (03) : 153 - 158
[47] On the antioxidant activity of ortho- and meta-substituted indolin-2-one derivatives
Najafi, Meysam
MONATSHEFTE FUR CHEMIE, 2014, 145 (02): : 291 - 299
[48] Synthesis of some 4-thiazolidinone derivatives as antitubercular agents.
Parekh, HH
Parikh, AR
Parikh, K
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 219 : U30 - U30
[49] Synthesis and pharmacological evaluation of some new 4-thiazolidinone derivatives
Kaneria, DJ
Datta, NJ
Khunt, RC
Parekh, HH
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2003, 12 (03) : 277 - 278
[50] THE INVESTIGATION OF BENZ[C,D]INDOLIN-2-ONE DERIVATIVES - THE BROMINATION OF BENZ[C,D]INDOLIN-2-ONE CARBOXYLIC-ACIDS
BYSTRITSKII, GI
RODIONOVA, GN
YELETSKAYA, SV
SHEBAN, GV
VOROZHTSOV, GN
ZAITSEV, BY
PARTALLA, NA
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1985, (10): : 1363 - 1367

← 1 2 3 4 5 →