Inflammation and insulin resistance

被引：1784

作者：

de Luca, Carl ^{[1
]}

Olefsky, Jerrold M. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med 0673, La Jolla, CA 92093 USA

来源：

FEBS LETTERS | 2008年 / 582卷 / 01期

关键词：

insulin resistance; inflammation; cytokines; macrophage;

D O I：

10.1016/j.febslet.2007.11.057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity-induced chronic inflammation is a key component in the pathogenesis of insulin resistance and the Metabolic syndrome. In this review, we focus on the interconnection between obesity, inflammation and insulin resistance. Proinflammatory cytokines can cause insulin resistance in adipose tissue, skeletal muscle and liver by inhibiting insulin signal transduction. The sources of cytokines in insulin resistant states are the insulin target tissue themselves, primarily fat and liver, but to a larger extent the activated tissue resident macrophages. While the initiating factors of this inflammatory response remain to be fully determined, chronic inflammation in these tissues could cause localized insulin resistance via autocrine/paracrine cytokine signaling and systemic insulin resistance via endocrine cytokine signaling all of which contribute to the abnormal metabolic state. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：97 / 105

页数：9

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