Ischemic stroke after recombinant factor VIIa treatment in acquired hemophilia A patient

被引：4

作者：

Katgi, Abdullah ^{[1
]}

Ataca, Pinar ^{[2
]}

Kahraman, Selda ^{[1
]}

Piskin, Ozden ^{[1
]}

Ozcan, Mehmet A. ^{[1
]}

Demirkan, Fatih ^{[1
]}

Ozsan, Guner H. ^{[1
]}

Undar, Bulent ^{[1
]}

机构：

[1] Dokuz Eylul Univ, Dept Hematol, TR-35470 Izmir, Turkey

[2] Dokuz Eylul Univ, Dept Internal Med, TR-35470 Izmir, Turkey

来源：

BLOOD COAGULATION & FIBRINOLYSIS | 2012年 / 23卷 / 01期

关键词：

acquired hemophilia; recombinant factor VIIa; thromboembolic attack; INHIBITORS; METAANALYSIS; THERAPY;

D O I：

10.1097/MBC.0b013e32834b8267

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acquired hemophilia is a rare, life-threatening coagulopathy in adults caused by the development of autoantibodies against factor VIII. Bypass agents such as recombinant factor VIIa (rFVIIa) are usually preferred for bleeding control; however, thromboembolic complications may occur. We report here a case that presented with extensive cutaneous and mucosal bleedings due to factor VIII inhibitors and was treated successfully with rFVIIa and steroid therapy, but was complicated with a life-threatening thromboembolic attack during follow-up. Blood Coagul Fibrinolysis 23:69-70 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：69 / 70

页数：2

共 11 条

[1] Recombinant factor VIIa: review of efficacy, dosing regimens and safety in patients with congenital and acquired factor VIII or IX inhibitors
Abshire, T
Kenet, G
[J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2004, 2 (06) : 899 - 909
[2] Acquired inhibitors
Cohen, AJ
Kessler, CM
[J]. BAILLIERES CLINICAL HAEMATOLOGY, 1996, 9 (02): : 331 - 354
[3] Treatment of acquired hemophilia A
Collins, P. W.
[J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2007, 5 (05) : 893 - 900
[4] Acquired haemophilia: Review and meta-analysis focused on therapy and prognostic factors
Delgado, J
Jimenez-Yuste, V
Hernandez-Navarro, F
Villar, A
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 2003, 121 (01) : 21 - 35
[5] Acquired hemophilia A: A concise review
Franchini, M
Gandini, G
Di Paolantonio, T
Mariani, G
[J]. AMERICAN JOURNAL OF HEMATOLOGY, 2005, 80 (01) : 55 - 63
[6] GREEN D, 1981, THROMB HAEMOSTASIS, V45, P200
[7] Hay CRM, 1997, THROMB HAEMOSTASIS, V78, P1463
[8] Successful response to rituximab in two cases of acquired haemophilia refractory to standard-therapy
Machado, P.
Raya, J. M.
Martin, T.
Morabiot, L.
Brito, M. L.
Rodriguez-Martin, J. M.
[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY, 2008, 87 (05) : 545 - 549
[9] Nicolaides AN, 2005, INT ANGIOL, V24, P1
[10] Stroke: epidemiology, clinical picture, and risk factors - Part I of III
Tegos, TJ
Kalodiki, E
Daskalopoulou, SS
Nicolaides, AN
[J]. ANGIOLOGY, 2000, 51 (10) : 793 - 808

← 1 2 →