Manganese Catalyzed Asymmetric Transfer Hydrogenation of Ketones Using Chiral Oxamide Ligands

被引：44
|
作者：
Schneekoenig, Jacob [1 ]
Junge, Kathrin [1 ]
Beller, Matthias [1 ]
机构：
[1] Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany
来源：
SYNLETT | 2019年 / 30卷 / 04期
关键词：
transfer hydrogenation; asymmetric; manganese; chiral ligands; ketones; ENANTIOSELECTIVE TRANSFER HYDROGENATION; ENANTIOMERIC RECOGNITION; IRON; MACROCYCLES; COMPLEX; EFFICIENT; GELATION; AMIDES; PNN;
D O I：
10.1055/s-0037-1611669
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The asymmetric transfer hydrogenation of ketones using isopropyl alcohol (IPA) as hydrogen donor in the presence of novel manganese catalysts is explored. The selective and active systems are easily generated in situ from [MnBr(CO)(5)] and inexpensive C-2-symmeric bisoxalamide ligands. Under the optimized reaction conditions, the Mn-derived catalyst gave higher enantioselectivity compared with the related ruthenium catalyst.
引用
收藏
页码：503 / 507
页数：5
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