An Efficient Synthesis of Pyrrolo[1,2-a]quinoxalines by CopperCatalyzed C-H Activation of Arylacetic Acids

被引：35

作者：

Lade, Jatin J. ^{[1
]}

Patil, Bhausaheb N. ^{[1
]}

Vhatkar, Mahendra V. ^{[1
]}

Vadagaonkar, Kamlesh S. ^{[2
]}

Chaskar, Atul C. ^{[1
,2
]}

机构：

[1] Univ Mumbai, Natl Ctr Nanosci & Nanotechnol, Kalina Campus, Bombay 400098, Maharashtra, India

[2] Inst Chem Technol, Dept Dyestuff Technol, Nathalal Parekh Marg, Bombay 400019, Maharashtra, India

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 6卷 / 11期

关键词：

arylacetic acid; C-H activation; copper; pyrroles; quinoxalines; REGIOSELECTIVE SYNTHESIS; ANTIMALARIAL ACTIVITY; POTENTIAL INHIBITORS; BRONSTED ACID; DERIVATIVES;

D O I：

10.1002/ajoc.201700239

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and convenient synthesis of pyrrolo[1,2-a]quinoxalines from 1-(2-aminoaryl) pyrrole and arylacetic acids has been described by using a combination of CuSO4 as the catalyst and 2,2'-bipyridyl as the ligand in the presence of O-2 as an oxidant. The prominent features of this method are the use of readily available starting materials, inexpensive catalyst, broad substrate scope and high product yields.

引用

页码：1579 / 1583

页数：5

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