Current perspectives on naturally occurring saponins as anticancer agents

被引：13
作者：
Wang, Ruo [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China
来源：
ARCHIV DER PHARMAZIE | 2022年 / 355卷 / 05期
关键词：
anticancer activity; natural products; saponins; steroidal; triterpenoidal; TRITERPENOID SAPONINS; GLIOBLASTOMA;
D O I：
10.1002/ardp.202100469
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Saponins, a heterogeneous group of sterol and triterpene glycosides, are distributed widely in nature. Naturally occurring saponins could act on diverse targets in cancer cells and consequently exert potential antiproliferative effects in various cancers, including drug-resistant forms. Therefore, naturally occurring saponins are useful templates for the discovery of novel anticancer candidates. Covering articles published between January 2020 and October 2021, this review aims to outline the recent development of naturally occurring steroidal and triterpenoidal saponins with anticancer potential to provide novel anticancer lead hits/candidates.
引用
收藏
页数：9
相关论文
共 63 条
  • [31] Triterpenoid saponins from Calliandra calothyrsus Meisn. and their antiproliferative activity against two digestive carcinoma human cell lines
    Messi, Lin Marcellin
    Placide Note, Olivier
    Mbing, Josephine Ngo
    Lavedan, Pierre
    Vedrenne, Marc
    Ouedraogo, Noufou
    Carraz, Maelle
    Bourgeade-Delmas, Sandra
    Pegnyemb, Dieudonne Emmanuel
    Haddad, Mohamed
    [J]. FITOTERAPIA, 2020, 146
  • [32] Triterpenoid Saponin AG8 from Ardisia gigantifolia stapf. Induces Triple Negative Breast Cancer Cells Apoptosis through Oxidative Stress Pathway
    Mu, Li-Hua
    Wang, Li-Hua
    Yu, Teng-Fei
    Wang, Yu-Ning
    Yan, Hong
    Liu, Ping
    Yan, Can
    [J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2020, 2020
  • [33] Arenarosides A-G, Polyhydroxylated Oleanane-Type Saponins from Polycarpaea arenaria and their Cytotoxic and Antiangiogenic Activities
    Nguyen, Nham-Linh
    Vo, Thanh-Hoa
    Lin, Yu-Chi
    Liaw, Chia-Ching
    Lu, Mei-Kuang
    Cheng, Jing-Jy
    Chen, Mei-Chuan
    Kuo, Yao-Haur
    [J]. JOURNAL OF NATURAL PRODUCTS, 2021, 84 (02): : 259 - 267
  • [34] Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-κB pathway
    Pang, Dejiang
    Yang, Chengcheng
    Li, Chao
    Zou, Yuanfeng
    Feng, Bin
    Li, Lixia
    Liu, Wentao
    Luo, Qihui
    Chen, Zhengli
    Huang, Chao
    [J]. BIOLOGY OPEN, 2020, 9 (02):
  • [35] Saponins as cytotoxic agents: a review
    Podolak, Irma
    Galanty, Agnieszka
    Sobolewska, Danuta
    [J]. PHYTOCHEMISTRY REVIEWS, 2010, 9 (03) : 425 - 474
  • [36] Paris saponin VII extracted from Trillium tschonoskii induces autophagy and apoptosis in NSCLC cells
    Qian, Shijing
    Tong, Shanshan
    Wu, Juan
    Tian, Lulu
    Qi, Zhan
    Chen, Beilei
    Zhu, Deqiu
    Zhang, Yan
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2020, 248
  • [37] New hydroperoxylated and 20,24-epoxylated dammarane triterpenes from the rot roots of Panax notoginseng
    Shang, Jia-Huan
    Sun, Wen-Jie
    Zhu, Hong-Tao
    Wang, Dong
    Yang, Chong-Ren
    Zhang, Ying-Jun
    [J]. JOURNAL OF GINSENG RESEARCH, 2020, 44 (03) : 405 - 412
  • [38] Saponins as cytotoxic agents: an update (2010-2018). Part I-steroidal saponins
    Sobolewska, Danuta
    Galanty, Agnieszka
    Grabowska, Karolina
    Makowska-Was, Justyna
    Wrobel-Biedrawa, Dagmara
    Podolak, Irma
    [J]. PHYTOCHEMISTRY REVIEWS, 2020, 19 (01) : 139 - 189
  • [39] Triterpenoid saponins and phenylpropanoid glycoside from the roots of Ardisia crenata and their cytotoxic activities
    Song Ning-Ning
    Yang Lei-Min
    Zhang Min-Jie
    An Ren-Feng
    Liu Wei
    Huang Xue-Feng
    [J]. CHINESE JOURNAL OF NATURAL MEDICINES, 2021, 19 (01) : 63 - 69
  • [40] Coumarin derivatives with anticancer activities: An update
    Song Xu-Feng
    Fan Jing
    Liu Lan
    Liu Xiao-Feng
    Gao Feng
    [J]. ARCHIV DER PHARMAZIE, 2020, 353 (08)
1234567