Current perspectives on naturally occurring saponins as anticancer agents

被引：13
作者：
Wang, Ruo [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China
来源：
ARCHIV DER PHARMAZIE | 2022年 / 355卷 / 05期
关键词：
anticancer activity; natural products; saponins; steroidal; triterpenoidal; TRITERPENOID SAPONINS; GLIOBLASTOMA;
D O I：
10.1002/ardp.202100469
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Saponins, a heterogeneous group of sterol and triterpene glycosides, are distributed widely in nature. Naturally occurring saponins could act on diverse targets in cancer cells and consequently exert potential antiproliferative effects in various cancers, including drug-resistant forms. Therefore, naturally occurring saponins are useful templates for the discovery of novel anticancer candidates. Covering articles published between January 2020 and October 2021, this review aims to outline the recent development of naturally occurring steroidal and triterpenoidal saponins with anticancer potential to provide novel anticancer lead hits/candidates.
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页数：9
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