The strong MRI relaxivity of paramagnetic nanoparticles

被引：51

作者：

Xing, Gengmei ^{[1
]}

Yuan, Hui ^{[1
]}

He, Rui ^{[1
]}

Gao, Xueyun ^{[1
]}

Jing, Long ^{[1
]}

Zhao, Feng ^{[1
]}

Chai, Zhifang ^{[1
]}

Zhao, Yuliang ^{[2
]}

机构：

[1] Chinese Acad Sci, Lab Bioenvironm Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China

[2] Natl Ctr Nanosci & Technol, Beijing 100080, Peoples R China

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2008年 / 112卷 / 20期

关键词：

D O I：

10.1021/jp8012706

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We developed a method to synthesize paramagnetic nanoparticles of Gd@C-82(OH)(22 +/- 2). Such nanoparticles are with ordered microstructures and have strong MRI proton relaxation in vitro/vivo. Compared with commercial Gd-DTPA, a 12 x MRI relaxivity of Gd@C-82(OH)(22 +/- 2) nanoparticles with ordered microstructures was achieved in vitro. The small Gd@C-82(OH)(22 +/- 2) nanoparticles, similar to 65nm, could easily escape the RES uptake in vivo; this opens the door for their clinical applications.

引用

页码：6288 / 6291

页数：4

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