Coated-platelets: an emerging component of the procoagulant response

被引：215

作者：

Dale, GL ^{[1
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Med, WK Warren Med Res Inst, Oklahoma City, OK 73104 USA

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2005年 / 3卷 / 10期

关键词：

COAT-platelet; fibrinogen; platelet; serotonin; thrombospondin; transglutaminase;

D O I：

10.1111/j.1538-7836.2005.01274.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Coated-platelets, formerly known as COAT-platelets, represent a subpopulation of cells observed after dual agonist stimulation of platelets with collagen and thrombin. This class of platelets retains on its surface high levels of several procoagulant proteins, including fibrinogen, von Willebrand factor, fibronectin, factor V and thrombospondin. Coated-platelets also express surface phosphatidylserine and strongly support prothrombinase activity. Retention of alpha-granule proteins on the surface of coated-platelets involves an unexpected derivatization of these proteins with serotonin and an interaction of serotonin-conjugated proteins with serotonin binding sites on fibrinogen and thrombospondin. This review will also detail experimental systems where coated-platelets are generated as a result of other agonist(s). Finally, the putative physiological consequences of coated-platelet formation will be discussed.

引用

页码：2185 / 2192

页数：8

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