CLC-3 Chloride Channels in the Pulmonary Vasculature

被引：8

作者：

Hume, Joseph R. ^{[1
]}

Wang, Ge-Xin ^{[1
]}

Yamazaki, Jun ^{[2
]}

Lih Chyuan Ng ^{[1
]}

Duan, Dayue ^{[1
]}

机构：

[1] Univ Nevada, Sch Med, Dept Pharmacol, Ctr Biomed Res Excellence, Reno, NV 89557 USA

[2] Fukuoka Dent Coll, Dept Physiol Sci & Mol Biol, Fukuoka, Japan

来源：

MEMBRANE RECEPTORS, CHANNELS AND TRANSPORTERS IN PULMONARY CIRCULATION | 2010年 / 661卷

基金：

美国国家卫生研究院;

关键词：

Chloride channels; cell volume; pulmonary artery; ClC-3; SMOOTH-MUSCLE-CELLS; VOLUME-SENSITIVE OSMOLYTE; CILIARY EPITHELIAL-CELLS; ACTIVATED CL-CURRENTS; ANION CHANNELS; EXPRESSION; PROTEINS; RAT; PROLIFERATION; INHIBITION;

D O I：

10.1007/978-1-60761-500-2_15

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Volume-sensitive outwardly rectifying anion channels (VSOACs) are expressed in pulmonary artery smooth muscle cells (PASMCs) and have been implicated in cell proliferation, growth, apoptosis and protection against oxidative. stress. In this chapter, we review the properties of native VSOACs in PASMCs, and consider the evidence that ClC-3, a member of the ClC superfamily of voltage dependent Cl- channels, may be responsible for native VSOACs in PASMCs. Finally, we examine whether or not native VSOACs and heterologously expressed ClC-3 channels function as bona fide chloride channels or as chloride/proton antiporters.

引用

页码：237 / 247

页数：11

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