Serotonin 2C Receptor Activates a Distinct Population of Arcuate Pro-opiomelanocortin Neurons via TRPC Channels

被引：163

作者：

Sohn, Jong-Woo ^{[1
]}

Xu, Yong ^{[1
,3
]}

Jones, Juli E. ^{[4
]}

Wickman, Kevin ^{[5
]}

Williams, Kevin W. ^{[1
]}

Elmquist, Joel K. ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Hypothalam Res, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA

[3] Baylor Coll Med, Dept Pediat, Childrens Nutr Res Ctr, Houston, TX 77030 USA

[4] Harvard Univ, Sch Med, Dept Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA

[5] Univ Minnesota, Dept Pharmacol, Minneapolis, MN 55455 USA

来源：

NEURON | 2011年 / 71卷 / 03期

关键词：

ENERGY HOMEOSTASIS REGULATION; GATED POTASSIUM CHANNELS; RECTIFYING K+ CHANNELS; MELANOCORTIN PATHWAYS; AGRP NEURONS; GLUCOSE-HOMEOSTASIS; D-FENFLURAMINE; POMC NEURONS; FOOD-INTAKE; I-KACH;

D O I：

10.1016/j.neuron.2011.06.012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Serotonin 2C receptors (5-HT(2C)Rs) expressed by pro-opiomelanocortin (POMC) neurons of hypothalamic arcuate nucleus regulate food intake, energy homeostasis and glucose metabolism. However, the cellular mechanisms underlying the effects of 5-HT to regulate POMC neuronal activity via 5-HT(2C)Rs have not yet been identified. In the present study, we found the putative transient receptor potential C (TRPC) channels mediate the activation of a subpopulation of POMC neurons by mCPP (a 5-HT(2C)R agonist). Interestingly, mCPP-activated POMC neurons were found to be a distinct population from those activated by leptin. Together, our data suggest that 5-HT(2C)R and leptin receptors are expressed by distinct subpopulations of arcuate POMC neurons and that both 5-HT and leptin exert their actions in POMC neurons via TRPC channels.

引用

页码：488 / 497

页数：10

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