Oxidatively Generated Damage to DNA by UVA Radiation in Cells and Human Skin

被引：85

作者：

Cadet, Jean ^{[1
]}

Douki, Thierry ^{[1
]}

机构：

[1] FRE CNRS 3200, Lab Les Acides Nucl, SCIB UMR E CEA UJF 3, Dept Rech Fondamentale Matiere Condensee, Grenoble, France

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2011年 / 131卷 / 05期

关键词：

ULTRAVIOLET;

D O I：

10.1038/jid.2011.51

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Exposure of cells and human skin to UVA radiation oxidatively induces damage to DNA that consists mostly of 8-oxo-7,8-dihydroguanine (8-oxoGua), together with relatively minor amounts of oxidized pyrimidine bases and oligonucleotide strand breaks. Singlet oxygen generated by the type II photosensitization mechanism forms 8-oxoGua, with a small contribution by hydroxyl radicals. The mechanisms of UVA-mediated formation of DNA oxidation products indicate the absence of induction of double-strand breaks.

引用

页码：1005 / 1007

页数：4

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