Oxidatively Generated Damage to DNA by UVA Radiation in Cells and Human Skin

被引：84
|
作者：
Cadet, Jean [1 ]
Douki, Thierry [1 ]
机构：
[1] FRE CNRS 3200, Lab Les Acides Nucl, SCIB UMR E CEA UJF 3, Dept Rech Fondamentale Matiere Condensee, Grenoble, France
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2011年 / 131卷 / 05期
关键词：
ULTRAVIOLET;
D O I：
10.1038/jid.2011.51
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Exposure of cells and human skin to UVA radiation oxidatively induces damage to DNA that consists mostly of 8-oxo-7,8-dihydroguanine (8-oxoGua), together with relatively minor amounts of oxidized pyrimidine bases and oligonucleotide strand breaks. Singlet oxygen generated by the type II photosensitization mechanism forms 8-oxoGua, with a small contribution by hydroxyl radicals. The mechanisms of UVA-mediated formation of DNA oxidation products indicate the absence of induction of double-strand breaks.
引用
收藏
页码：1005 / 1007
页数：4
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