Epigenetic changes in osteosarcoma

被引：27

作者：

Cui, Juncheng ^{[1
]}

Wang, Wanchun ^{[1
]}

Li, Zhihong ^{[1
]}

Zhang, Zhaogui ^{[1
]}

Wu, Bei ^{[2
]}

Zeng, Li ^{[3
]}

机构：

[1] Cent S Univ, Xiangya Hosp 2, Dept Orthoped, Changsha, Hunan, Peoples R China

[2] Cent S Univ, Xiangya Hosp, Dept Orthoped, Changsha, Hunan, Peoples R China

[3] Nanhua Univ, Affiliated Hosp 1, Dept Med Cosmetol, Hengyang, Hunan, Peoples R China

来源：

BULLETIN DU CANCER | 2011年 / 98卷 / 07期

关键词：

osteosarcoma; epigenetics; DNA methylation; histone modifications; HISTONE DEACETYLASE INHIBITORS; SQUAMOUS-CELL CARCINOMA; DNA METHYLATION; GENE-EXPRESSION; CHONDROMODULIN-I; PROMOTER REGION; RECQL4; GENE; CPG ISLANDS; MYC GENE; CANCER;

D O I：

10.1684/bdc.2011.1400

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Osteosarcoma is one of the most prevalent primary bone tumors. The pathogenesis and molecular development of this tumor remains elusive. The prognosis is unfavorable due to lack of effective treatment methods. Recent advances in the epigenetics have brought a profound impact on the understanding of molecular mechanisms that lead to osteosarcoma. In this review, we summarized the current literature on epigenetic changes that are thought to contribute to the carcinogenesis of osteosarcoma, and discussed the potential diagnostic and therapeutic applications as well as future areas of research.

引用

页码：E62 / E68

页数：7

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