Diminished AMPK signaling response to fasting in thioredoxin-interacting protein knockout mice

被引：19
作者：
Andres, Allen M. [2 ]
Ratliff, Eric P. [2 ]
Sachithanantham, Sowbarnika [2 ]
Hui, Simon T. [1 ,2 ]
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Div Cardiol, Dept Med, Los Angeles, CA 90095 USA
[2] San Diego State Univ, Dept Biol, BioSci Ctr, San Diego, CA 92182 USA
来源：
FEBS LETTERS | 2011年 / 585卷 / 08期
关键词：
Cellular AMP level; Mitochondrial oxidation; Glucose homeostasis; Glycogen storage; GLUCOSE-TRANSPORT; OXIDATIVE STRESS; GENE-EXPRESSION; KINASE; INSULIN; TXNIP; LKB1; IDENTIFICATION; DEFICIENCY; REGULATOR;
D O I：
10.1016/j.febslet.2011.03.042
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Thioredoxin-interacting protein (Txnip) knockout (TKO) mice exhibit impaired response to fasting. Herein, we showed that activation of adenine monophosphate-activated protein kinase and cellular AMP levels were diminished in the heart and soleus muscle but not in gastrocnemius muscle of fasting TKO mice. Similarly, glycogen content in fasted TKO mice was increased in oxidative muscles but was not different in glycolytic muscles. These data suggest Txnip deficiency has a higher impact on oxidative muscle than glycolytic muscles and provide new insights into the metabolic role of Txnip. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
引用
收藏
页码：1223 / 1230
页数：8
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