New drugs are not enough-drug repositioning in oncology: An update

被引：68

作者：

Armando, Romina Gabriela ^{[1
]}

Gomez, Diego Luis Mengual ^{[1
]}

Gomez, Daniel Eduardo ^{[1
]}

机构：

[1] Natl Univ Quilmes, Sci & Technol Dept, Lab Mol Oncol, Roque Saenz Pena 352,B1876, Bernal, Argentina

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2020年 / 56卷 / 03期

关键词：

drug; repositioning; repurposing; oncology; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; HIV PROTEASE INHIBITORS; CANCER STEM-CELLS; PHOSPHODIESTERASE TYPE 5; HUMAN PROSTATE-CANCER; PHASE-II TRIAL; OVEREXPRESSING TISSUE INHIBITOR; MYELOID-LEUKEMIA MECHANISMS; CALCIUM-CHANNEL ANTAGONISTS; ENDOTHELIAL GROWTH-FACTOR;

D O I：

10.3892/ijo.2020.4966

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that are already known for use treating other diseases. The advantages of this are that several important drug characteristics are already established (including efficacy, pharmacokinetics, pharmacodynamics and toxicity), making the process of research for a putative drug quicker and less costly. Drug repositioning in oncology has received extensive focus. The present review summarizes the most prominent examples of drug repositioning for the treatment of cancer, taking into consideration their primary use, proposed anticancer mechanisms and current development status.

引用

收藏

页码：651 / 684

页数：34

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