Mutant mice lacking the cholecystokinin2 receptor show a dopamine-dependent hyperactivity and a behavioral sensitization to morphine

被引：21

作者：

Daugé, V

Beslot, F

Matsui, T

Roques, BP

机构：

[1] UFR Sci Pharmaceut & BIol, Dept Pharmacochim Mol & Struct, CNRS,UMR 8600, INSERM,U266, F-75270 Paris 06, France

[2] Kobe Univ, Sch Med, Dept Med, Div 3,Chuo Ku, Kobe, Hyogo 6500017, Japan

来源：

NEUROSCIENCE LETTERS | 2001年 / 306卷 / 1-2期

关键词：

cholecystokinin(2) receptor-deficient mice; morphine; amphetamine; cocaine; dopamine antagonists; sensitization;

D O I：

10.1016/S0304-3940(01)01867-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cholecystokinin(2) (CCK2) receptor-deficient mice were used to analyze the in vivo function of CCK2 receptor and especially the incidence of this gene invalidation on enkephalinergic and dopaminergic systems. Hyperlocomotor activity of CCK2 receptor-deficient mice was suppressed by a selective D2 antagonist but not by a D1 antagonist. Injection of amphetamine induced a hyperlocomotor activity in both groups of mice while mutant mice were less sensitive to cocaine. Administration of 6 mg/kg of morphine once every 2 days for 5 days significantly (P < 0.05) enhanced motor activity the last day compared to the first day, only in CCK2 receptor-deficient mice. These results emphasize the role of CCK2 receptors in counteracting the effects of dopaminergic systems and suggest that CCK2 receptor invalidation could lead to a slight behavioral sensitization. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：41 / 44

页数：4

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