Glia instruct developmental neuronal remodeling through TGF-β signaling

被引：109

作者：

Awasaki, Takeshi ^{[1
,2
]}

Huang, Yaling ^{[1
,2
]}

O'Connor, Michael B. ^{[3
,4
]}

Lee, Tzumin ^{[1
,2
]}

机构：

[1] Univ Massachusetts, Dept Neurobiol, Worcester, MA 01605 USA

[2] Howard Hughes Med Inst, Ashburn, VA USA

[3] Univ Minnesota, Howard Hughes Med Inst, Minneapolis, MN USA

[4] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN USA

来源：

NATURE NEUROSCIENCE | 2011年 / 14卷 / 07期

基金：

美国国家卫生研究院;

关键词：

DROSOPHILA METAMORPHOSIS; RECEPTOR; REQUIREMENT; MYOGLIANIN; EXPRESSION; SYSTEM; BRAIN;

D O I：

10.1038/nn.2833

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We found that glia secrete myoglianin, a TGF-beta ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.

引用

页码：821 / 823

页数：3

共 15 条

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