Glia instruct developmental neuronal remodeling through TGF-β signaling

被引：114

作者：

Awasaki, Takeshi ^{[1
,2
]}

Huang, Yaling ^{[1
,2
]}

O'Connor, Michael B. ^{[3
,4
]}

Lee, Tzumin ^{[1
,2
]}

机构：

[1] Univ Massachusetts, Dept Neurobiol, Worcester, MA 01605 USA

[2] Howard Hughes Med Inst, Ashburn, VA USA

[3] Univ Minnesota, Howard Hughes Med Inst, Minneapolis, MN USA

[4] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN USA

来源：

NATURE NEUROSCIENCE | 2011年 / 14卷 / 07期

基金：

美国国家卫生研究院;

关键词：

DROSOPHILA METAMORPHOSIS; RECEPTOR; REQUIREMENT; MYOGLIANIN; EXPRESSION; SYSTEM; BRAIN;

D O I：

10.1038/nn.2833

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We found that glia secrete myoglianin, a TGF-beta ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.

引用

页码：821 / 823

页数：3

共 15 条

[11] Axon pruning during Drosphila metamorphosis:: Evidence for local degeneration and requirement of the ubiquitin-proteasome system [J].

Watts, RJ ;

Hoopfer, ED ;

Luo, LQ .

NEURON, 2003, 38 (06) :871-885

[12] Glia engulf degenerating axons during developmental axon pruning [J].

Watts, RJ ;

Schuldiner, O ;

Perrino, J ;

Larsen, C ;

Luo, LQ .

CURRENT BIOLOGY, 2004, 14 (08) :678-684

[13] Baboon/dSmad2 TGF-β signaling is required during late larval stage for development of adult-specific neurons [J].

Zheng, XY ;

Zugates, CT ;

Lu, ZY ;

Shi, L ;

Bai, JM ;

Lee, T .

EMBO JOURNAL, 2006, 25 (03) :615-627

[14] TGF-β signaling activates steroid hormone receptor expression during neuronal remodeling in the Drosophila brain [J].

Zheng, XY ;

Wang, J ;

Haerry, TE ;

Wu, AYH ;

Martin, J ;

O'Connor, MB ;

Lee, CHJ ;

Lee, T .

CELL, 2003, 112 (03) :303-315

[15] Drosophila Activin-β and the Activin-like product Dawdle function redundantly to regulate proliferation in the larval brain [J].

Zhu, Changqi C. ;

Boone, Jason Q. ;

Jensen, Philip A. ;

Hanna, Scott ;

Podemski, Lynn ;

Locke, John ;

Doe, Chris Q. ;

O'Connor, Michael B. .

DEVELOPMENT, 2008, 135 (03) :513-521

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