Glia instruct developmental neuronal remodeling through TGF-β signaling

被引：114

作者：

Awasaki, Takeshi ^{[1
,2
]}

Huang, Yaling ^{[1
,2
]}

O'Connor, Michael B. ^{[3
,4
]}

Lee, Tzumin ^{[1
,2
]}

机构：

[1] Univ Massachusetts, Dept Neurobiol, Worcester, MA 01605 USA

[2] Howard Hughes Med Inst, Ashburn, VA USA

[3] Univ Minnesota, Howard Hughes Med Inst, Minneapolis, MN USA

[4] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN USA

来源：

NATURE NEUROSCIENCE | 2011年 / 14卷 / 07期

基金：

美国国家卫生研究院;

关键词：

DROSOPHILA METAMORPHOSIS; RECEPTOR; REQUIREMENT; MYOGLIANIN; EXPRESSION; SYSTEM; BRAIN;

D O I：

10.1038/nn.2833

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We found that glia secrete myoglianin, a TGF-beta ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.

引用

页码：821 / 823

页数：3

共 15 条

[1] Essential role of the apoptotic cell engulfment genes draper and ced-6 in programmed axon pruning during Drosophila metamorphosis [J].

Awasaki, T ;

Tatsumi, R ;

Takahashi, K ;

Arai, K ;

Nakanishi, Y ;

Ueda, R ;

Ito, K .

NEURON, 2006, 50 (06) :855-867

[2] Engulfing action of glial cells is required for programmed axon pruning during Drosophila metamorphosis [J].

Awasaki, T ;

Ito, K .

CURRENT BIOLOGY, 2004, 14 (08) :668-677

[3] Orphan nuclear receptors control neuronal remodeling during fly metamorphosis [J].

Awasaki, Takeshi ;

Lee, Tzumin .

NATURE NEUROSCIENCE, 2011, 14 (01) :6-7

[4] The Drosophila Activin-like ligand Dawdle signals preferentially through one isoform of the Type-I receptor Baboon [J].

Jensen, Philip A. ;

Zheng, Xiaoyan ;

Lee, Tzumin ;

O'Connor, Michael B. .

MECHANISMS OF DEVELOPMENT, 2009, 126 (11-12) :950-957

[5]

Lee T, 1999, DEVELOPMENT, V126, P4065

[6] Cell-autonomous requirement of the USP/EcR-B ecdysone receptor for mushroom body neuronal remodeling in Drosophila [J].

Lee, T ;

Marticke, S ;

Sung, C ;

Robinow, S ;

Luo, LQ .

NEURON, 2000, 28 (03) :807-818

[7] The Drosophila type II receptor, Wishful thinking, binds BMP and myoglianin to activate multiple TGFβ family signaling pathways [J].

Lee-Hoeflich, ST ;

Zhao, X ;

Mehra, A ;

Attisano, L .

FEBS LETTERS, 2005, 579 (21) :4615-4621

[8] Sequence and expression of myoglianin, a novel Drosophila gene of the TGF-β superfamily [J].

Lo, PCH ;

Frasch, M .

MECHANISMS OF DEVELOPMENT, 1999, 86 (1-2) :171-175

[9] Developmentally programmed remodeling of the Drosophila olfactory circuit [J].

Marin, EC ;

Watts, RJ ;

Tanaka, NK ;

Ito, K ;

Luo, LQ .

DEVELOPMENT, 2005, 132 (04) :725-737

[10] METAMORPHOSIS OF THE CENTRAL-NERVOUS-SYSTEM OF DROSOPHILA [J].

TRUMAN, JW .

JOURNAL OF NEUROBIOLOGY, 1990, 21 (07) :1072-1084

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