Glia instruct developmental neuronal remodeling through TGF-β signaling

被引：109
作者：
Awasaki, Takeshi [1 ,2 ]
Huang, Yaling [1 ,2 ]
O'Connor, Michael B. [3 ,4 ]
Lee, Tzumin [1 ,2 ]
机构：
[1] Univ Massachusetts, Dept Neurobiol, Worcester, MA 01605 USA
[2] Howard Hughes Med Inst, Ashburn, VA USA
[3] Univ Minnesota, Howard Hughes Med Inst, Minneapolis, MN USA
[4] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN USA
来源：
NATURE NEUROSCIENCE | 2011年 / 14卷 / 07期
基金：
美国国家卫生研究院;
关键词：
DROSOPHILA METAMORPHOSIS; RECEPTOR; REQUIREMENT; MYOGLIANIN; EXPRESSION; SYSTEM; BRAIN;
D O I：
10.1038/nn.2833
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We found that glia secrete myoglianin, a TGF-beta ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.
引用
收藏
页码：821 / 823
页数：3
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