TM or not TM: transmembrane protein prediction with low false positive rate using DAS-TMfilter

被引：78

作者：

Cserzo, M

Eisenhaber, F

Eisenhaber, B

Simon, I

机构：

[1] Agr Biotechnol Ctr, H-2100 Godollo, Hungary

[2] IMP Bioinformat, A-1030 Vienna, Austria

[3] Hungarian Acad Sci, Biol Res Ctr, Inst Enzymol, H-1518 Budapest, Hungary

来源：

BIOINFORMATICS | 2004年 / 20卷 / 01期

基金：

匈牙利科学研究基金会; 奥地利科学基金会;

关键词：

D O I：

10.1093/bioinformatics/btg394

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Web-based servers implementing the DAS-TMfilter algorithm have been launched at three mirror sites and their usage is described. The underlying computer program is an upgraded and modified version of the DAS-prediction method. The new server is designed to make distinction between protein sequences with and without transmembrane (TM) helices at a reasonably low rate of false positive prediction (similar to1 among 100 unrelated queries) while the high efficiency of the original algorithm locating TM segments in queries is preserved (sensitivity of similar to95% among documented proteins with helical TM regions).

引用

页码：136 / 137

页数：2

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