Pro-oxidant activity of flavonoids: Effects on glutathione and glutathione S-transferase in isolated rat liver nuclei

被引：92

作者：

Sahu, SC

Gray, GC

机构：

[1] Division of Toxicological Research, Ctr. for Food Safety and Appl. Nutr., US Food and Drug Administration, Laurel

来源：

CANCER LETTERS | 1996年 / 104卷 / 02期

关键词：

flavonoids; glutathione; glutathione S-transferase; oxidative stress;

D O I：

10.1016/0304-3835(96)04251-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effects of three representative flavonoids, quercetin, myricetin and kaempferol, on the nuclear antioxidant defense glutathione (GSH) and glutathione S-transferase (GST) were investigated in a model system of isolated rat liver nuclei. The three flavonoids induced a concentration-dependent decrease of both the nuclear GSH content and GST activity. Myricetin, which has the maximum number of hydroxyl groups, was the most active. The results demonstrate the pro-oxidant activity of these polyphenolic flavonoids. The impairment of the nuclear antioxidant defense GSH and GST by the polyphenolic flavonoids can lead to oxidative DNA damage, which may be responsible for their mutagenicity.

引用

页码：193 / 196

页数：4

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