How vaccinia virus has evolved to subvert the host immune response

被引：61

作者：

Bahar, Mohammad W. ^{[1
,2
]}

Graham, Stephen C. ^{[1
,2
]}

Chen, Ron A. -J. ^{[3
]}

Cooray, Samantha ^{[3
]}

Smith, Geoffrey L. ^{[3
]}

Stuart, David I. ^{[1
,2
,4
]}

Grimes, Jonathan M. ^{[1
,2
,4
]}

机构：

[1] Univ Oxford, Div Struct Biol, Oxford OX3 7BN, England

[2] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford Prot Prod Facil, Oxford OX3 7BN, England

[3] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Virol, London W2 1PG, England

[4] Diamond Light Source Ltd, Div Sci, Didcot OX11 0DE, Oxon, England

来源：

JOURNAL OF STRUCTURAL BIOLOGY | 2011年 / 175卷 / 02期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

Structural virology; Innate immunity; Cell signalling; X-ray crystallography; Surface receptors; NF-KAPPA-B; NECROSIS-FACTOR RECEPTOR; TOLL-LIKE-RECEPTORS; PROTEIN-KINASE PKR; RNA HELICASE DDX3; POXVIRUS PROTEIN; STRUCTURAL BASIS; APOPTOTIC PROTEIN; CRYSTAL-STRUCTURE; BINDING-PROTEIN;

D O I：

10.1016/j.jsb.2011.03.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Viruses are obligate intracellular parasites and are some of the most rapidly evolving and diverse pathogens encountered by the host immune system. Large complicated viruses, such as poxviruses, have evolved a plethora of proteins to disrupt host immune signalling in their battle against immune surveillance. Recent X-ray crystallographic analysis of these viral immunomodulators has helped form an emerging picture of the molecular details of virus-host interactions. In this review we consider some of these immune evasion strategies as they apply to poxviruses, from a structural perspective, with specific examples from the European SPINE2-Complexes initiative. Structures of poxvirus immunomodulators reveal the capacity of viruses to mimic and compete against the host immune system, using a diverse range of structural folds that are unique or acquired from their hosts with both enhanced and unexpectedly divergent functions. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：127 / 134

页数：8

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