Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures

被引：424
作者：
Peng, Ying [1 ,2 ]
Ao, Mingyue [1 ,2 ]
Dong, Baohua [1 ,2 ]
Jiang, Yunxiu [1 ,2 ]
Yu, Lingying [1 ,2 ]
Chen, Zhimin [1 ,2 ]
Hu, Changjiang [1 ,2 ,3 ]
Xu, Runchun [1 ,2 ]
机构：
[1] Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Pharm Coll, Chengdu, Peoples R China
[3] Neo Green Pharmaceut Co Ltd, Chengdu, Peoples R China
来源：
DRUG DESIGN DEVELOPMENT AND THERAPY | 2021年 / 15卷
基金：
中国博士后科学基金;
关键词：
anti-inflammatory; osteoarthritis; psoriasis; atherosclerotic; pharmacokinetics; prodrug; SIGNALING PATHWAY; INDUCED COLITIS; DOUBLE-BLIND; RECEPTOR; 4; IN-VITRO; PSORIASIS; ATHEROSCLEROSIS; DELIVERY; CELLS; METAANALYSIS;
D O I：
10.2147/DDDT.S327378
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Curcumin is a natural compound with great potential for disease treatment. A large number of studies have proved that curcumin has a variety of biological activities, among which anti-inflammatory effect is a significant feature of it. Inflammation is a complex and pervasive physiological and pathological process. The physiological and pathological mechanisms of inflammatory bowel disease, psoriasis, atherosclerosis, COVID-19 and other research focus diseases are not clear yet, and they are considered to be related to inflammation. The anti-inflammatory effect of curcumin can effectively improve the symptoms of these diseases and is expected to be a candidate drug for the treatment of related diseases. This paper mainly reviews the anti-inflammatory effect of curcumin, the inflammatory pathological mechanism of related diseases, the regulatory effect of curcumin on these, and the latest research results on the improvement of curcumin pharmacokinetics. It is beneficial to the further study of curcumin and provides new ideas and insights for the development of curcumin anti-inflammatory preparations.
引用
收藏
页码：4503 / 4525
页数：23
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