Review of Anti-Bacterial Activities of Curcumin against Pseudomonas aeruginosa

被引:19
作者
Neyestani, Zohreh [1 ]
Ebrahimi, Seyed Ali [2 ]
Ghazaghi, Anahita [2 ]
Jalili, Amin [3 ]
Sahebkar, Amirhossein [4 ,5 ,6 ]
Rahimi, Hamid Reza [4 ]
机构
[1] Islamic Azad Univ, Neyshabur Branch, Fac Sci, Dept Microbiol, Neyshabur, Iran
[2] Islamic Azad Univ, Mashhad Branch, Student Res Comm, Mashhad, Razavi Khorasan, Iran
[3] Mashhad Univ Med Sci, Fac Med, Dept Med Biotechnol, Mashhad, Razavi Khorasan, Iran
[4] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran
[5] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran
[6] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran
来源
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION | 2019年 / 29卷 / 05期
关键词
bacterial infections; Pseudomonas aeruginosa; curcumin; quorum sensing; GRAM-NEGATIVE BACTERIA; OUTER-MEMBRANE; VIRULENCE; NANOPARTICLES; PERMEABILITY; INHIBITION; REGULATOR; INFECTION; PROTEIN; LONGA;
D O I
10.1615/CritRevEukaryotGeneExpr.2019029088
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The prevention and pharmacotherapy of infectious diseases are of great importance. Among others, infections caused by Pseudomonas aeruginosa have a high mortality rate. This bacterium is the third most common cause of nosocomial infections, and characteristics such as multiple virulence factors, ability to survive, environmental spread, and resistance to antibiotics have made it a potential pathogen, especially for people with compromised immune systems. Considering bacterial resistance to current medications, high cost, and side effects, the need to provide new and effective therapies is highlighted. Curcumin is a dietary polyphenolic compound that has a wide range of therapeutic properties, including antibacterial effects. It has been the subject of increasing research exploring its potential utility in infectious diseases. In this review, the antibacterial effects of curcumin against Pseudomonas aeruginosa are discussed.
引用
收藏
页码:377 / 385
页数:9
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