Modulation of Monoamine Receptors by Adaptor Proteins and Lipid Rafts: Role in Some Effects of Centrally Acting Drugs and Therapeutic Agents

被引：22

作者：

Bjork, Karl ^{[1
]}

Svenningsson, Per ^{[1
]}

机构：

[1] Karolinska Inst, Ctr Mol Med, SE-17177 Stockholm, Sweden

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 51, 2011 | 2011年 / 51卷

关键词：

dopamine; serotonin; GF CR; caveolin; scaffolding proteins; ligand bias; 5-HT2A SEROTONIN RECEPTORS; HUMAN 5-HT7(A) RECEPTORS; D-1; DOPAMINE-RECEPTOR; BETA-ADRENERGIC-RECEPTORS; MEDIATED ERK ACTIVATION; CELL-SURFACE EXPRESSION; 3RD INTRACELLULAR LOOP; KNOCK-OUT MICE; COUPLED-RECEPTORS; BETA(1)-ADRENERGIC RECEPTOR;

D O I：

10.1146/annurev-pharmtox-010510-100520

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The monoamines and their cognate receptors are widespread in the central nervous system and are vital for normal brain function. Dysfunction in these systems underlies severa consequently monoamin. review provides an over by adaptor proteins and cells. Monoamine recept binding sites for adaptor by cholesterol and subm (interactions determine se function including traffi(adaptor proteins and lipi drugs and therapeutic ag psychiatric and neurological disease states, and is are targets of a host of pharmacotherapies. This iew on how monoamine receptors are regulated lipid rafts with emphasis on interactions in nerve irs have prominent intracellular loops that provide proteins. Receptor function is further modulated mbranous microdomains termed lipid rafts. These 7eral facets of G protein coupled receptor (GPCR) king, localization, and signaling. Possible roles of I rafts in disease states and in mediating actions of;nts are also discussed.

引用

页码：211 / 242

页数：32

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