Cardiac troponins: are there any differences between T and I?

被引：20
作者：
Perrone, Marco A. [1 ,2 ]
Storti, Simona [3 ,4 ]
Salvadori, Stefano [5 ]
Pecori, Alessandro [5 ]
Bernardini, Sergio [6 ]
Romeo, Francesco [2 ]
Guccione, Paolo [1 ]
Clerico, Aldo [3 ,4 ]
机构：
[1] Bambino Gesu Childrens Hosp IRCCS, Dept Pediat Cardiol & Cardiac Surg, Piazza S Onofrio 4, I-00165 Rome, Italy
[2] Univ Roma Tor Vergata, Div Cardiol, Rome, Italy
[3] Heart Hosp, CNR Reg Toscana G Monasterio Fdn, Massa, Italy
[4] Scuola Super Sant Anna, Pisa, Italy
[5] CNR, Inst Clin Physiol, Pisa, Italy
[6] Univ Roma Tor Vergata, Div Clin Biochem & Clin Mol Biol, Rome, Italy
来源：
JOURNAL OF CARDIOVASCULAR MEDICINE | 2021年 / 22卷 / 11期
关键词：
acute myocardial infarction; cardiac troponin I; cardiac troponin T; high-sensitivity methods; myocardial injury; ACUTE MYOCARDIAL-INFARCTION; HIGH-SENSITIVITY ASSAY; GENERAL-POPULATION; RULE-OUT; CIRCULATING CONCENTRATIONS; CARDIOVASCULAR OUTCOMES; DIAGNOSTIC PROTOCOL; 2-HOUR ALGORITHM; RELEASE KINETICS; PROGNOSTIC VALUE;
D O I：
10.2459/JCM.0000000000001155
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The most recent international guidelines recommend the measurement of cardiac troponin I (cTnI) and cardiac troponin T (cTnT) using high-sensitivity methods (hs-cTn) for the detection of myocardial injury and the differential diagnosis of acute coronary syndromes. Myocardial injury is a prerequisite for the diagnosis of acute myocardial infarction, but also a distinct entity. The 2018 Fourth Universal Definition of Myocardial Infarction states that myocardial injury is detected when at least one value above the 99th percentile upper reference limit is measured in a patient with high-sensitivity methods for cTnI or cTnT. Not infrequently, increased hs-cTnT levels are reported in patients with congenital or chronic neuromuscular diseases, while the hs-cTnI values are often in the normal range. Furthermore, some discrepancies between the results of laboratory tests for the two troponins are occasionally found in individuals apparently free of cardiac diseases, and also in patients with cardiac diseases. In this review article, authors discuss the biochemical, pathophysiological and analytical mechanisms which may cause discrepancies between hs-cTnI and hs-cTnT test results.
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收藏
页码：797 / 805
页数：9
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