Peroxisome Proliferator-Activated Receptors in HBV-Related Infection

被引：12
作者：
Dubuquoy, Laurent [1 ,2 ,3 ]
Louvet, Alexandre [1 ,2 ,3 ]
Hollebecque, Antoine [1 ,2 ,3 ]
Mathurin, Philippe [1 ,2 ,3 ]
Dharancy, Sebastien [1 ,2 ,3 ]
机构：
[1] INSERM, U795, F-59037 Lille, France
[2] Univ Lille 2, F-59045 Lille, France
[3] CHRU, Hop Huriez, Serv Malad Appareil Digestif & Nutr, F-59037 Lille, France
来源：
PPAR RESEARCH | 2009年 / 2009卷
关键词：
HEPATITIS-B-VIRUS; NUCLEOCAPSID PROMOTER VARIANT; NUCLEAR HORMONE RECEPTORS; IN-VIVO; REPLICATION; EXPRESSION; ALPHA; TRANSCRIPTION; STEATOSIS; PROTEIN;
D O I：
10.1155/2009/145124
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Thirty years after its discovery, the hepatitis B virus (HBV) still remains a major global public health problem. Worldwide, two billion subjects have been infected, 350 million have a chronic infection and more than 600 000 die annually of HBV-related liver disease or hepatocellular carcinoma; new infections occur because of the presence of a large reservoir of chronic carriers of the virus. Since a decade several studies describe the interrelations between HBV and nuclear receptors and more particularly the peroxisome proliferator-activated receptors (PPARs). After a brief introduction, this review will make a rapid description of HBV incidence and biology. Then a report of the literature on the role of PPARs on viral transcription and replication will be developed. Finally, the role of HBV on PPAR. expression and activity will be discussed. Concluding remarks and perspectives will close this review. Copyright (C) 2009 Laurent Dubuquoy et al.
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页数：6
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